Results 141 to 150 of about 49,420 (307)
BMEMat, EarlyView.A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie +12 more
wiley +1 more source
Sentience in cephalopod molluscs: an updated assessment
Biological Reviews, EarlyView.ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell +4 more
wiley +1 more source
Nasal preparations: Conventional and advanced pharmaceutical dosage forms
, 2011 Nasal dosage forms (nasal preparations) are traditionally used for local drug delivery, often for cold and flu symptoms' therapy. Apart from conventional dosage forms such as nasal drops, ointments and gels and aqueous nasal products, nasal sprays are even more frequently used, where the active pharmaceutical ingredient can, depending on its solubility,
Savić, Snežana, Milić, Jela
openaire +1 more source
Cancer Nexus, EarlyView.ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han +5 more
wiley +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Virtual Reality Externalization (VR‐E) for Patients With Eating Disorders: A Pilot Study
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Despite significant health and psychosocial impairments, many individuals with eating disorders (ED) view their disorder as an integral part of their identity. Because this “ego‐syntonicity” is associated with low treatment motivation and treatment dropouts, we investigated the acceptability, feasibility, and effects of a newly ...
Samuel P. E. Mehranfar +4 more
wiley +1 more source