Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats [PDF]
International Journal of Molecular Sciences, 2022 Parkinson’s Disease (PD) is a brain-degenerative disorder characterized by a progressive loss of midbrain dopamine neurons. Current standard-of-care includes oral administration of Levodopa to address motor symptoms, but this treatment is not disease-modifying.
Ruben K. Dagda +4 more
europepmc +4 more sources
Study of surfactants influence on the noopept releasing from the nasal dosage form
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020 The nasal route of drug administration, as is well known, is characterized by some advantages: absorption rate and rapid onset of therapeutic effect, availability of drug delivery without hepatic first-pass elimination, it is suitable and easily ...
B. S. Burlaka +2 more
doaj +6 more sources
Zaporožskij Medicinskij Žurnal, 2021 Development of novel medications for delivery of active ingredients with systemic absorption and high bioavailability is an actual challenge for modern pharmaceutical and medical science.
B. S. Burlaka, I. F. Bielenichev
doaj +7 more sources
Study of excipients influence on the noopept releasing from the nasal dosage form
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019 The development of medicines for fast delivery is the actual direction of modern pharmacy. In this connection, the nasal route of drug administration is perspective and has some advantages. The greater permeability of nasal mucosa with large surface area
B. S. Burlaka +2 more
doaj +6 more sources
The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories [PDF]
Journal of XenobioticsIn recent years, an increasing number of case reports have mentioned the presence of illicit nootropics, smart drugs or mind doping products on the market.
Celine Vanhee +18 more
doaj +3 more sources
Heliyon, 2021 There are largely unknown associations between changes in pain behavior responses during persistent peripheral inflammation and spinal cell alteration such as apoptosis.
Mona Taghizadeh +8 more
doaj +2 more sources
Thermogravimetric investigation of a new intranasal gel with noopept
Фармацевтичний журнал, 2019 Recently, in the world, there is a negative dynamics of increasing diseases of the central nervous system. Creation of neuropeptide-based dosage forms with high pharmacological activity, neuroavailability and improved biopharmaceutical properties is an ...
B. S. Burlaka
doaj +4 more sources
Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept [PDF]
Acta Naturae, 2016 This study was performed in order to reveal the effect of Noopept (ethyl ester of N-phenylacetyl-Lprolylglycine, GVS-111) on the DNA-binding activity of transcriptional factors (TF) in HEK293 cells transiently transfected with luciferase reporter constructs containing sequences for CREB, NFAT, NF-B, p53, STAT1, GAS, VDR, HSF1, and HIF-1. Noopept (10 M)
VAKHITOVA Y.V. +5 more
openaire +4 more sources
Effects of noopept on cognitive functions and pubertal process in rats with diabetes
Life Sciences, 2019 Type 1 diabetes (T1DM) is a common chronic disease in childhood. Increasing insulin resistance in puberty gives rise to higher doses of insulin usage in treatment. Of this reason new approaches in treatment are needed. Noopept researches suggest it to have anti-diabetic properties.
Perihan Gurbuz +2 more
exaly +4 more sources
Retraction notice to “Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process” [Heliyon (2021) e06219] [PDF]
Heliyon, 2021 Mona Taghizadeh +8 more
doaj +2 more sources