Results 21 to 30 of about 133,855 (244)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Histopathologic parameters as predictors of response to endoscopic sinus surgery in nonallergic patients with chronic rhinosinusitis [PDF]

, 2006
OBJECTIVE: To estimate the predictable value of histopathologic parameters in chronic rhinosinusitis (CRS) for response to endoscopic sinus surgery (ESS).
Bhattacharyya N., Damm M, Dhong HJ, Drvi P, Dunlop G, Kaliner MA, Kalogjera L, Lavigne F, Marks SC, Watelet JB   +9 more
core   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage

Advanced Science, EarlyView.
This work designs an in situ proliferating peptide nanoparticle as a flexible resolution that modulates the neuro‐glia unit to enable enhanced multi‐target combinational therapy for secondary brain damage following subarachnoid hemorrhage. Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered ...
Yibin Zhang, Peisen Yao, Fuxiang Chen, Shufa Zheng, Xuegang Niu, Haojie Wang, Yuanxiang Lin, Bin Gao, Dezhi Kang   +8 more
wiley   +1 more source

Use of balloon catheter dilation and steroid-eluting stent in light and severe rhinosinusitis of frontal sinus: a multicenter retrospective randomized study [PDF]

, 2018
OBJECTIVE: Frontal sinus surgery has an increased rate of re-stenosis, if compared to other sinuses, that mainly depends on recurrent inflammation and abnormal scarring at the frontal recess; its reduction represents one of the keys of therapeutic ...
Azimonti, Dario, CAVALIERE, CARLO, DE VINCENTIIS, Marco, Dragonetti, Alberto, Franzetti, Andrea, MINNI, Antonio, RALLI, MASSIMO, ROSATI, DAVIDE, SCIUTO, Antonino   +8 more
core   +1 more source

Malignant melanoma of the nasal mucosa

Indian Journal of Otolaryngology and Head and Neck Surgery, 1999
Malignant melanoma of the nasal mucosa is a rare tumor. We present here a case which involved the nose and the paranasal sinuses. Though surgical excision was achieved, postoperative metastalic spread to the liver resulted in poor prognosis, necessitating chemotherapy. Relevant literature on the subject is reviewed.
Vikas Gupta, A Ravikumar
openaire   +4 more sources

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Effect of Laser Irradiation on sIg A and Mucosa Structure of Upper Respiratory Tract with Six-week Incremental Exercise [PDF]

, 2014
[Objective] Mucosal immune suppression, with chronic intensive exercise, can be associated with an increased risk of upper respiratory tract infections, which should be related to the deterioration of the nasal mucosa structure.
Hao, Xuanming, Liu, Chengyi, Qin, Fei, Wang, Liying, Xu, Jian   +4 more
core   +1 more source

Aminopeptidase activity in human nasal mucosa [PDF]

Journal of Allergy and Clinical Immunology, 1998
Aminopeptidases activate bradykinin and degrade many inflammatory peptides.The objective of this study was to identify the types of aminopeptidase activities in human nasal mucosa.Human nasal mucosa was homogenized (n = 12), and cytoplasmic (S2) and membrane-rich (P2) fractions were obtained.
Kimihiro Ohkubo, Michael A. Kaliner, James N. Baraniuk, Louis B. Hersh, Marco Merida, Robert J. Hohman   +5 more
openaire   +2 more sources