Results 191 to 200 of about 58,092 (289)

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, Volume 31, Issue 5, Page 484-497, May 2026.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

The Role of MUC1 in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP): The Correlation with Disease Severity. [PDF]

J Pers Med
Giancaspro R, Netti GS, De Luca F, Camporeale V, Catalano V, Cassano M, Ranieri E, Gelardi M.   +7 more
europepmc   +1 more source

Low-frequency ultrasound for biofilm disruption in chronic rhinosinusitis with nasal polyposis: In vitro pilot study [PDF]

, 2017
Csomor, Péter, Karosi, Tamás, Sziklai, István   +2 more
core   +1 more source

Nasal dermoid sinus cyst diagnosed on CT in an adult Hungarian Vizsla

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract Nasal dermoid sinus cysts are rare congenital anomalies in dogs, resulting from abnormal embryological development that leads to the inclusion of ectodermal and mesodermal elements within a sinus or subcutaneous tissue, along the dorsal midline.
Athena Kam, Kerry Peak, Kathryn Fleming, Andrew Phillips   +3 more
wiley   +1 more source

Impact of dupilumab on SNOT-22 domain and individual item scores in chronic rhinosinusitis with nasal polyps. [PDF]

Sci Rep
Lang A, Habenbacher M, Moser U, Pock J, Lampl T, Holzmeister C, Abaira A, Staudinger J, Andrianakis A.   +8 more
europepmc   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, Volume 81, Issue 5, Page 1617-1634, May 2026.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

A Literature Review of the Management of Nasal Polyps: Biologics Combined With Endoscopic Surgery. [PDF]

Cureus
Castillo Cortorreal ME, Martínez Areché AG, Román Ledesma S, De Los Santos Estevez RI, Fernandez Rodriguez AL, Quiles Robles GM, Eleazar O, Rosario Rosario A.   +7 more
europepmc   +1 more source

Heredity, symptoms and risk factors of nasal polyps [PDF]

, 2015
Anton Bohman, Martin Oscarsson, Mats Bende   +2 more
core   +1 more source

Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model

Allergy, Volume 81, Issue 5, Page 1459-1471, May 2026.
Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang, Jing Liu, Jing Ye, Li‐Ying Sun, Hsiao Hui Ong, Yang Peng, Bing‐Qi Lin, Jun‐Hao Tu, Ke‐Shuang Wang, Yi‐Shan Xiong, Qing Luo, Mark Thong, Yu Xu, De‐Yun Wang   +13 more
wiley   +1 more source

Navigating challenges in management of difficult-to-treat chronic rhinosinusitis with nasal polyps in the greater Gulf. [PDF]

Saudi Med J
Marglani OA, Razzak Juratli A, Maatouq Alwael A, Hussain Alokby G, Al Rayyes HYA, Alsharif SAA, Abo El Ezz TA.   +6 more
europepmc   +1 more source