Results 1 to 10 of about 22,731 (179)

Study of Different Local Treatments of Post COVID-19 Smell Dysfunction [PDF]

Iranian Journal of Otorhinolaryngology, 2022
Introduction:This study was designed to differentiate between the impact of the topical nasal spray of corticosteroids, antihistamines, a combination of them, and normal 0.2% saline in treating patients with post-coronavirus disease 2019 (COVID-19) smell
Soad Mohamad, Ahmed Badwy, Ramy El-Sabaa, Hosam Ahmad, Asmaa Mohamed   +4 more
doaj   +1 more source

Importance of Spray–Wall Interaction and Post-Deposition Liquid Motion in the Transport and Delivery of Pharmaceutical Nasal Sprays

Pharmaceutics, 2022
Nasal sprays, which produce relatively large pharmaceutical droplets and have high momentum, are primarily used to deliver locally acting drugs to the nasal mucosa.
Arun V. Kolanjiyil, Ali Alfaifi, Ghali Aladwani, Laleh Golshahi, Worth Longest   +4 more
doaj   +1 more source

Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study

Frontiers in Pharmacology, 2022
Background: The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children.Methods: Part 1:
Yun Kuang, Sai-Ying Wang, Meng-Na Wang, Guo-Ping Yang, Guo-Ping Yang, Guo-Ping Yang, Can Guo, Shuang Yang, Xing-Fei Zhang, Xiao-Yan Yang, Qi Pei, Chan Zou, Chan Zou, Yan-Hong He, Ying-Yong Zhou, Kai-Ming Duan, Jie Huang, Jie Huang   +17 more
doaj   +1 more source

Management of treatment-resistant depression with esketamine nasal spray: clinical questions for daily practice in Gulf Cooperation Council countries

Middle East Current Psychiatry, 2023
Background There is a high unmet need among patients with treatment-resistant depression (TRD) as treatment with standard therapies is associated with low response and remission rates and high rates of relapse.
Nahida Nayaz Ahmed, Faisal Albishi, Suhail A. Khan, Ammar Alsayegh, Emmanuel Stip, Samer Makhoul   +5 more
doaj   +1 more source

Semi-PBPK Modeling and Simulation to Evaluate the Local and Systemic Pharmacokinetics of OC-01(Varenicline) Nasal Spray

Frontiers in Pharmacology, 2022
This study aimed to build a nasal semi-physiologically based pharmacokinetic (PBPK) model to predict the intranasal pharmacokinetic (PK) of the OC-01(varenicline) nasal spray and accelerate the development of this drug.
Xiaofei Wu, Fan Zhang, Mengyang Yu, Faming Ding, Jinghui Luo, Bo Liu, Yuan Li, Zhiping Li, Hongyun Wang   +8 more
doaj   +1 more source

Effect of short-course glucocorticoid application on patients with chronic rhinosinusitis with nasal polyps

World Allergy Organization Journal, 2020
Background: Local and systemic glucocorticoids are mainstay therapies for chronic rhinosinusitis. With respect to local glucocorticoids, nasal spray is used extensively, but some patients do not benefit from short-course treatment.
Zhaofeng Xu, Xin Luo, Lei Xu, Jie Deng, Wenxiang Gao, Lijie Jiang, Zhaoqi Huang, Jianbo Shi, Yinyan Lai   +8 more
doaj   +1 more source

A nasal spray vaccination device based on Laval nozzle and its experimental test

Scientific Reports, 2023
In order to realize the application of the nasal spray vaccination in the prevention and protection of respiratory infectious diseases, a nasal spray vaccination device is designed in this paper.
Zhong Wang, Zhengyuan Zhang, Qian Wang, Lingliao Zeng, Jian Jin   +4 more
doaj   +1 more source

Using nasal sprays to prevent respiratory tract infections: a qualitative study of online consumer reviews and primary care patient interviews

BMJ Open, 2022
Objectives Nasal sprays could be a promising approach to preventing respiratory tract infections (RTIs). This study explored lay people’s perceptions and experiences of using nasal sprays to prevent RTIs to identify barriers and facilitators to their ...
Paul Little, Katherine Bradbury, Lucy Yardley, Adam W A Geraghty, Ben Ainsworth, Kate Greenwell, Deb Smith, Laura Dennison, Sian Williamson, James Denison-Day, Fiona Mowbray, Samantha Richards-Hall   +11 more
doaj   +1 more source

Adenosine Triphosphate Bioluminescence Test of the Nasal Spray Nozzles Attached to an Ear-nose-throat Treatment Unit

Tokyo Women's Medical University Journal, 2018
To report a proper protocol for cleaning and disinfecting the nozzles attached to ear-nose-throat (ENT) treatment unit, contamination of nasal spray nozzle, nasal speculum, and suction tube before and after use was assessed by adenosine triphosphate (ATP)
Yukie YAMAMURA, Tomoko EGAWA, Yukako SEO, Manabu NONAKA   +3 more
doaj   +1 more source

Nasal immune gene expression in response to azelastine and fluticasone propionate combination or monotherapy

Immunity, Inflammation and Disease, 2022
Background The combination of the antihistamine azelastine (AZE) with the corticosteroid fluticasone propionate (FP) in a single spray, has been reported to be significantly more effective at reducing allergic rhinitis (AR) symptoms than treatment with ...
Annabelle M. Watts, Nicholas P. West, Peter K. Smith, Ping Zhang, Allan W. Cripps, Amanda J. Cox   +5 more
doaj   +1 more source