Results 1 to 10 of about 846,625 (333)
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Nature, 2021 Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of patients for optimal ...
Dominik Pfister, , Roser Pinyol
exaly +2 more sources
Signal Transduction and Targeted Therapy, 2022 Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive and more susceptible to developing cirrhosis and hepatocellular carcinoma ...
Chenyang Zhao
exaly +2 more sources
Current and future pharmacological therapies for NAFLD/NASH
Journal of Gastroenterology, 2017 Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and there is no approved pharmacotherapy. The efficacy of vitamin E and pioglitazone has been established in nonalcoholic steatohepatitis (NASH), a progressive form ...
Yoshio Sumida
exaly +2 more sources
Noninvasive, Quantitative Assessment of Liver Fat by MRI‐PDFF as an Endpoint in NASH Trials
Hepatology, 2018 Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease worldwide, and the progressive form of this condition, nonalcoholic steatohepatitis (NASH), has become one of the leading indications for liver ...
Cyrielle Caussy +2 more
exaly +2 more sources
Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH.
New England Journal of Medicine, 2023 BACKGROUND Pegozafermin is a long-acting glycopegylated (pegylated with the use of site-specific glycosyltransferases) fibroblast growth factor 21 (FGF21) analogue in development for the treatment of nonalcoholic steatohepatitis (NASH) and severe ...
R. Loomba +16 more
semanticscholar +1 more source
تخمین جریان زیرسطحی دامنههای حوضه آبخیز با استفاده از مدلهای ناش و SCS [PDF]
مهندسی منابع آب, 2021 مقدمه: تخمین جریان زیرسطحی(SUF) در بسیاری از حوضههای آبریز با پوشش گیاهی مناسب و نفوذ پذیری خاک بالا حائز اهمیت است و نقش اساسی در تولید رواناب مستقیم حوضه دارد.
حسین فریبرزی +2 more
doaj +1 more source
Nature Microbiology, 2023 The gut commensal Parabacteroides distasonis uses inulin to produce the odd-chain fatty acid pentadecanoic acid, which alleviates non-alcoholic steatohepatitis via improved barrier function in mice. Non-alcoholic steatohepatitis (NASH) is the severe form
Wenchao Wei +13 more
semanticscholar +1 more source
Nature Communications, 2023 Axon regeneration of dorsal root ganglia (DRG) neurons after peripheral axotomy involves reconfiguration of gene regulatory circuits to establish regenerative gene programs. However, the underlying mechanisms remain unclear.
Dalia Halawani +7 more
doaj +1 more source
Obesity and binge alcohol intake are deadly combination to induce steatohepatitis: A model of high-fat diet and binge ethanol intake [PDF]
Clinical and Molecular Hepatology, 2020 Obesity and binge drinking often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. In this mini-review, we briefly summarize clinical evidence of the synergistical effect of obesity and heavy ...
Seonghwan Hwang, Tianyi Ren, Bin Gao
doaj +1 more source
A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH.
New England Journal of Medicine, 2021 BACKGROUND Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need. Lanifibranor is a pan-PPAR (peroxisome proliferator-activated receptor) agonist that modulates key metabolic, inflammatory, and fibrogenic pathways in the ...
S. Francque +26 more
semanticscholar +1 more source