Results 91 to 100 of about 30,077 (242)

Infiltrating B-cell subtypes and associated hub genes in nasopharyngeal carcinoma identified from integrated single-cell, bulk RNA-sequencing, and immunohistochemical data

Hereditas
Background Nasopharyngeal carcinoma (NPC) is associated with lymphocyte infiltration; however, the majority of research on NPC has focused on the role of T cells, with relatively little known about the roles of B cells and their subtypes.
Fangyan Zhong, Junjun Chen, Tianzhu Lu, Lin Zhang, Zhiliang Liu, Chunhong Guan, Xiaopeng Xiong, Xiaochang Gong, Jingao Li   +8 more
doaj   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Test-retest reliability of a computer-assisted self-administered questionnaire on early life exposure in a nasopharyngeal carcinoma case-control study

Scientific Reports, 2018
We evaluated the reliability of early life nasopharyngeal carcinoma (NPC) aetiology factors in the questionnaire of an NPC case-control study in Hong Kong during 2014–2017.
Zhi-Ming Mai, Jia-Huang Lin, Shing-Chun Chiang, Roger Kai-Cheong Ngan, Dora Lai-Wan Kwong, Wai-Tong Ng, Alice Wan-Ying Ng, Kam-Tong Yuen, Kai-Ming Ip, Yap-Hang Chan, Anne Wing-Mui Lee, Sai-Yin Ho, Maria Li Lung, Tai-Hing Lam   +13 more
doaj   +1 more source

Deep convolution neural network model for automatic risk assessment of patients with non-metastatic nasopharyngeal carcinoma [PDF]

arXiv, 2019
Nasopharyngeal Carcinoma (NPC) is endemic cancer in the south-east Asia. With the advent of intensity-modulated radiotherapy excellent locoregional control are being achieved. Consequently, this had led to pretreatment clinical staging classification to be less prognostic of outcomes such as recurrence after treatment.
arxiv  

On TRacK With Larotrectinib in a Neonate With a Giant Congenital ETV6::NTRK3 Fusion‐Positive Infantile Fibrosarcoma of the Head and Neck

Head &Neck, EarlyView.
ABSTRACT Background Infantile fibrosarcoma (IFS) is a rare pediatric tumor of intermediate malignancy with high local aggressiveness that typically presents in young infants. Its occurrence in the head and neck region is rare. Complete non‐mutilating surgical resection is often not possible, requiring multimodal treatment.
Teresa M. Cardesa‐Salzmann, Monika Sparber‐Sauer, Peter Hingst, Andreas Erbersdobler, Bjoern Schneider, Maja Hühns, Andre Jakob, Friederike Terpe, Christian Spang, Dorothea Stalmann, Claudia Bierwirth, Christina Hauenstein, Stefanie Märzheuser, Manfred Ballmann, Carl Friedrich Classen   +14 more
wiley   +1 more source

Vision Changes After Head and Neck Cancer Treatment

Head &Neck, EarlyView.
ABSTRACT Background Literature about ocular toxicity after head and neck cancer (HNC) treatment is scarce. This study aimed to describe visual function and ocular symptoms among HNC patients. Methods The study used a cross‐sectional design. Two surveys, The National Eye Institute Visual Functioning Questionnaire (NEI‐VFQ) and an Ocular Symptom Scale ...
Hsiao‐Lan Wang, Megan Heskett, Peng Li, Laura Dreer, David Vance, Susan McCammon, Kailei Yan, Amanda Elliott   +7 more
wiley   +1 more source

Mitophagy: A novel perspective for insighting into cancer and cancer treatment

Cell Proliferation, Volume 55, Issue 12, December 2022., 2022
Mitophagy is a physiological process regulated by complex and diverse mechanisms. Here we summarize the 15 main molecular mechanisms involved in the mammalian mitophagy processes and some potential anticancer drugs targeting mitophagy. Abstract Background Mitophagy refers to the selective self‐elimination of mitochondria under damaged or certain ...
Congkuan Song, Shize Pan, Jinjin Zhang, Ning Li, Qing Geng   +4 more
wiley   +1 more source

Classification of Nasopharyngeal Cases using DenseNet Deep Learning Architecture [PDF]

arXiv
Nasopharyngeal carcinoma (NPC) is one of the understudied yet deadliest cancers in South East Asia. In Malaysia, the prevalence is identified mainly in Sarawak, among the ethnic of Bidayuh. NPC is often late-diagnosed because it is asymptomatic at the early stage.
arxiv  

Differences in PD‐L1, PD‐L2, and EGFR Expression Between Naive and Recurrent Tumors in Patients With Head and Neck Squamous Cell Carcinoma: A Retrospective Study

Head &Neck, EarlyView.
ABSTRACT Background The efficacy of anti‐PD‐1 and EGFR therapies for head and neck squamous cell carcinoma (HNSCC) can be predicted using various markers; however, the stability of these markers remains unclear. Methods In this retrospective study, laboratory findings and tissue expression of PD‐L1, PD‐L2, and EGFR were analyzed in 79 paired naive and ...
Ryosuke Sato, Takahiro Inoue, Risa Wakisaka, Hiroki Komatsuda, Michihisa Kono, Hidekiyo Yamaki, Kenzo Ohara, Takumi Kumai, Akemi Kosaka, Takayuki Ohkuri, Toshihiro Nagato, Kan Kishibe, Hiroya Kobayashi, Miki Takahara   +13 more
wiley   +1 more source

Accurate and Efficient Detection of Nasopharyngeal Carcinoma Using Multi‐Dimensional Features of Plasma Cell‐Free DNA

Head &Neck, EarlyView.
ABSTRACT Background The incidence of Nasopharyngeal carcinoma (NPC) is rising in recent years, especially in some non‐developed parts of the world. Hence, cost‐efficient means for sensitive detection of NPC are vital. Methods We recruited 646 participants, including healthy individuals, patients with benign nasopharyngeal diseases, and NPC patients for
Song Zhang, Jiahui Tang, Pin Cui, Weihuang He, Xiaohui Lin, Shubing Wang, Yuanxian Liu, Xiaohua Tan, Shu Xu, Mingji Feng, Hanming Lai   +10 more
wiley   +1 more source