Results 91 to 100 of about 48,656 (208)

GERD and Upper Aerodigestive Tract Cancer Risk: A Systematic Review and Meta‐Analysis

The Laryngoscope, EarlyView.
ABSTRACT Objective Gastroesophageal reflux disease (GERD) is highly prevalent, yet its association with upper aerodigestive tract (UADT) cancers beyond esophageal adenocarcinoma remains incompletely defined. This systematic review and meta‐analysis aimed to quantify the risk of specific UADT cancers in individuals with GERD.
Janice Huang, Nicolas Jo, Garret Forman, Tonya Aaron, Sophia Peifer, Soumil Prasad, Luke van Leeuwen, Laura Wild, Nicholas DiStefano, Zhibin Chen, Elizabeth Franzmann   +10 more
wiley   +1 more source

Efficacy and safety of cadonilimab (PD-1/CTLA-4 bispecific) in combination with chemotherapy in anti-PD-1-resistant recurrent or metastatic nasopharyngeal carcinoma: a single-arm, open-label, phase 2 trial

BMC Medicine
Background We aimed to evaluate the efficacy and safety of cadonilimab (anti-PD-1 and CTLA-4 bispecific antibody) plus TPC chemotherapy (NAB-paclitaxel, cisplatin or lobaplatin, and capecitabine) in patients with recurrent or metastatic nasopharyngeal ...
Yaofei Jiang, Weixin Bei, Lin Wang, Nian Lu, Cheng Xu, Hu Liang, Liangru Ke, Yanfang Ye, Shuiqing He, Shuhui Dong, Qin Liu, Chuanrun Zhang, Xuguang Wang, Weixiong Xia, Chong Zhao, Ying Huang, Yanqun Xiang, Guoying Liu   +17 more
doaj   +1 more source

Unilateral Nasopharyngeal Endoscopic Resection Type III: Technical Notes 

The Laryngoscope, EarlyView.
The present video case report details technical notes of Nasopharyngeal Endoscopic Resection (NER) Type III, performed for a mucosal melanoma in a 71‐year‐old patient. Key surgical steps—such as achieving optimal exposure, employing Doppler‐guided internal carotid artery localization, and applying vascularized flap coverage—are outlined, demonstrating ...
Carlo Conti, Gabriele Testa, Davide Mattavelli, Vittorio Rampinelli, Claudia Lodovica Modesti, Aurora Pinacoli, Alberto Schreiber, Cesare Piazza   +7 more
wiley   +1 more source

Efficacy of metastasis-directed therapy in de novo metastatic nasopharyngeal carcinoma patients receiving chemo-immunotherapy and local regional radiotherapy: a multicenter retrospective study

BMC Cancer
Objective To develop a prognostic model that predicts outcomes and identifies ideal candidates for metastasis-directed therapy (MDT) in patients with de novo metastatic nasopharyngeal carcinoma (dmNPC) after chemo-immunotherapy and locoregional ...
Shui-Qing He, Shu-Hui Lv, Si-Qing Wen, Lin Wang, Ya-Hui Yu, Guo-Yi Zhang, Ding-Sheng Peng, Wei-Xin Bei, Chun-Lan Chen, Ze-Yu Zhao, Ying Huang, Yan-Qun Xiang, Guo-Ying Liu   +12 more
doaj   +1 more source

Choice and Death: Analysis of Medical Assistance in Dying for Head and Neck Cancer in Ontario

The Laryngoscope, EarlyView.
The uptake of MAiD for head and neck cancer (HNC) has been steadily increasing since 2016, when MAiD first became available in Canada. Our study projects a substantial increase in the future use of MAiD for patients with HNC. As such, our health system needs to re‐evaluate and implement the necessary infrastructure to support the projected increase in ...
Tanika Curry, Emily Wener, Michael Odell, Lisa Caulley, Rashi Ramchandani, Alyssa Grant, Kednapa Thavorn, Andrea Lasso, Shaun Kilty   +8 more
wiley   +1 more source

Universality of a mesenchymal transition signature in invasive solid cancers [PDF]

, 2012
In this brief communication, additional computational validation is provided consistent with the unifying hypothesis that a shared biological mechanism of mesenchymal transition, reflected by a precise gene expression signature, may be present in all ...
Dimitris Anastassiou
core   +1 more source

Genetic Factors Leading to Chronic Epstein–Barr Virus Infection and Nasopharyngeal Carcinoma in South East China: Study Design, Methods and Feasibility [PDF]

, 2006
Nasopharyngeal carcinoma (NPC) is a complex disease caused by a combination of Epstein-Barr virus chronic infection, the environment and host genes in a multi-step process of carcinogenesis.
David, Victor, de The, Guy, Dean, Michael, Deng, Hong, Dilks, Holli H., Guan, Li, Guo, Xiu Chan, Johnson, Randall C., Kessing, Bailey, Lautenberger, J. A., Liao, Jian, Liu, Yan, Martenson, Janice S., Nelson, George W., O\u27Brien, Stephen J., Scott, Kevin, Sun, Shan, Winkler, Cheryl, Zeng, Yi, Zheng, Yuming   +19 more
core   +2 more sources

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Combination strategy exploration for prior treated recurrent or metastatic nasopharyngeal carcinoma in the era of immunotherapy

Scientific Reports
To assess the efficacy and safety of the combination of immune checkpoint inhibitors (ICIs) and target therapy (anti-angiogenesis or EGFR inhibitors) as a second-line or subsequent treatment for recurrent or metastatic nasopharyngeal carcinoma (R/M NPC),
Yaofei Jiang, Chun Chen, Guoying Liu, Ting Fang, Nian Lu, Weixin Bei, Shuhui Dong, Wangzhong Li, Weixiong Xia, Hu Liang, Yanqun Xiang   +10 more
doaj   +1 more source

Microbial and epigenetic factors in the pathogenesis of nasopharyngeal carcinoma [PDF]

, 2015
While uncommon in most of the world, nasopharyngeal carcinoma (NPC) shows an unusual geographic and ethnic distribution, being highly prevalent in Southern China and Southeast Asia.
Zhou, Xiaoying
core   +1 more source