Results 41 to 50 of about 1,451,429 (415)

A global view of the oncogenic landscape in nasopharyngeal carcinoma : an integrated analysis at the genetic and expression levels [PDF]

, 2012
Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesis of
Amari, Aicha, Arrand, J. R. (John R.), Bell, Andrew I., Chen, Xiaoyi, Dawson, Christopher W., Derkaoui, K. Dalia, Hu, Chunfang, Joab, Irène, Maloney, Stephanie L., Murray, Paul G., Nicholls, J. M. (John M.), Shao, Jian-Yong, Sihota, Sim K., Wei, Wenbin, Woodman, Ciaran B. J., Yao, Yunhong, Young, Lawrence S.   +16 more
core   +4 more sources

Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo. [PDF]

, 2015
BackgroundMany patients with nasopharyngeal carcinoma (NPC) face poor prognosis. Due to its hidden anatomical location, the tumor is usually diagnosed quite late, and despite initially successful treatment with radiation and cisplatin, many patients will
Chen, Thomas C, Cho, Hee-Yeon, Hofman, Florence M, Nguyen, Jenny, Schönthal, Axel H, Singh, Anupam, Wang, Weijun, Wetzel, Stephanie J   +7 more
core   +2 more sources

Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma

Signal Transduction and Targeted Therapy, 2020
Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck region which mainly distributes in southern China and Southeast Asia and has a crucial association with the Epstein–Barr virus.
Yuanbo Kang, Weihan He, C. Ren, J. Qiao, Q. Guo, Jingyu Hu, Hong-juan Xu, Xingjun Jiang, Lei Wang   +8 more
semanticscholar   +1 more source

Focus on nasopharyngeal carcinoma [PDF]

Cancer Cell, 2004
Support from the Hong Kong Research Grant Council (CUHK 4301/99M; 4071/02M; 4067/02M; 410/03M; and HKUST 2/03C) and the Kadoorie Charitable Foundation is gratefully acknowledged.
Kwok Wai Lo, Ka Fai To, Dolly P. Huang
openaire   +3 more sources

The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3β/snail signalling

Journal of Experimental & Clinical Cancer Research, 2018
Background Distant metastasis is the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC). Although several biomarkers correlate with metastasis and prognosis, the molecular mechanisms of NPC development and progression remain
Wen-Ze Qiu, Hai-Bo Zhang, Wei-Xiong Xia, Liang-Ru Ke, Jing Yang, Ya-Hui Yu, Hu Liang, Xin-Jun Huang, Guo-Ying Liu, Wang-Zhong Li, Yan-Qun Xiang, Tie-Bang Kang, Xiang Guo, Xing Lv   +13 more
doaj   +1 more source

Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma.

New England Journal of Medicine, 2019
BACKGROUND Platinum-based concurrent chemoradiotherapy is the standard of care for patients with locoregionally advanced nasopharyngeal carcinoma. Additional gemcitabine and cisplatin induction chemotherapy has shown promising efficacy in phase 2 trials.
Y. Zhang, Lei Chen, G. Hu, Ning Zhang, Xiao-dong Zhu, Kun-yu Yang, F. Jin, M. Shi, Yupei Chen, Wei‐han Hu, Zhi-Bin Cheng, Si-yang Wang, Ye Tian, Xicheng Wang, Yan Sun, Jin-Gao Li, Wen-Fei Li, Y. Li, Ling-long Tang, Y. Mao, G. Zhou, R. Sun, Xu Liu, R. Guo, Guo-Xian Long, Shaoqiang Liang, Ling Li, Jing-yu Huang, J. Long, J. Zang, Qiao-dan Liu, Li Zou, Qiongqiong Su, B. Zheng, Yun Xiao, Ying Guo, F. Han, H. Mo, J. Lv, Xiao-jing Du, Cheng Xu, Na Liu, Yingqin Li, M. Chua, F. Xie, Ying Sun, Jun Ma   +46 more
semanticscholar   +1 more source

CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes [PDF]

, 2006
Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes,
Chan, A. T. C., Gudgeon, N. H., Hui, E. P., Jia, H., Lin, C. K., Lin, X., Rickinson, A. B., Taylor, G. S., Tsang, C. W.   +8 more
core   +1 more source

Stratification of Candidates for Induction Chemotherapy in Stage III-IV Nasopharyngeal Carcinoma: A Large Cohort Study Based on a Comprehensive Prognostic Model

Frontiers in Oncology, 2020
Objective: To establish a prognostic index (PI) for patients with stage III-IV nasopharyngeal carcinoma (NPC) patients to personalize recommendations for induction chemotherapy (IC) before intensity-modulated radiotherapy (IMRT).Patients and Methods ...
Xue-Song Sun, Xue-Song Sun, Bei-Bei Xiao, Bei-Bei Xiao, Zi-Jian Lu, Zi-Jian Lu, Sai-Lan Liu, Sai-Lan Liu, Qiu-Yan Chen, Qiu-Yan Chen, Li Yuan, Lin-Quan Tang, Lin-Quan Tang, Hai-Qiang Mai, Hai-Qiang Mai   +14 more
doaj   +1 more source

Development of a Nomogram Model for Treatment of Nonmetastatic Nasopharyngeal Carcinoma

JAMA Network Open, 2020
Key Points Question Could a prognostic nomogram that integrates the TNM staging system with other critical variables accurately predict overall survival and guide treatment in patients with nonmetastatic nasopharyngeal carcinoma?
Lu-Lu Zhang, Fei Xu, Di Song, Meng-yao Huang, Y. Huang, Qinqin Deng, Yi-yang Li, J. Shao   +7 more
semanticscholar   +1 more source

Exosomes in Nasopharyngeal Carcinoma [PDF]

Journal of Cancer, 2018
Exosomes are nanosized (30-100nm) membrane microvesicles secreted through a complex cellular process. Exosomes contain a variety of bioactive molecules, such as proteins, microRNAs(miRNAs or miRs) and long non-coding RNAs (lncRNAs), playing an important role in the cell-to-cell substance transportation and signal transduction.
Linda Oyang, Yujuan Zhou, Yutong Tian, Jingguan Lin, Shiming Tan, Hui Wang, Longzheng Xia, Heran Wang, Min Su, Qianjin Liao, Deliang Cao, Deliang Cao   +11 more
openaire   +2 more sources