Results 21 to 30 of about 73,649 (308)

TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models

Nature Communications, 2023
The molecular mechanisms determining the response to radiotherapy remain incompletely understood. Here, the authors demonstrate that the E3 ubiquitin ligase and intracellular Fc receptor, TRIM21, impairs CD8+ T cell responses in nasopharyngeal carcinoma ...
Jun-Yan Li, Yin Zhao, Sha Gong, Miao-Miao Wang, Xu Liu, Qing-Mei He, Ying-Qin Li, Sheng-Yan Huang, Han Qiao, Xi-Rong Tan, Ming-Liang Ye, Xun-Hua Zhu, Shi-Wei He, Qian Li, Ye-Lin Liang, Kai-Lin Chen, Sai-Wei Huang, Qing-Jie Li, Jun Ma, Na Liu   +19 more
doaj   +1 more source

Nasopharyngeal carcinoma [PDF]

Orphanet Journal of Rare Diseases, 2006
Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. The annual incidence of NPC in the UK is 0.3 per million at age 0-14 years, and 1 to 2 per million at age 15-19 years. Incidence is higher in the Chinese and Tunisian populations.
openaire   +3 more sources

Review of Nasopharyngeal Carcinoma [PDF]

Ear, Nose & Throat Journal, 2006
We review the literature on nasopharyngeal carcinoma that has been published within the past 5 years. Nasopharyngeal carcinoma is a highly morbid disease, and survival is poor. Its management remains extremely difficult, not just for otolaryngologists but for radiation oncologists and medical oncologists, as well.
Anita, Jeyakumar, Todd M, Brickman, Alwin, Jeyakumar, Timothy, Doerr   +3 more
openaire   +2 more sources

Influence of Epstein-Barr virus and human papillomavirus infection on macrophage migration inhibitory factor and macrophage polarization in nasopharyngeal carcinoma [PDF]

, 2023
三重大学博士(医学)application/pdfBackground: To assess the effects of Epstein–Barr virus (EBV) and human papillomavirus (HPV) infection on the tumor microenvironment, we examined the relationship between viral infection status, macrophage migration inhibitory ...
Feng, Guofei
core   +1 more source

Add-on individualizing prediction of nasopharyngeal carcinoma using deep-learning based on MRI: A multicentre, validation study

iScience, 2022
Summary: In nasopharyngeal carcinoma, deep-learning extracted signatures on MR images might be correlated with survival. In this study, we sought to develop an individualizing model using deep-learning MRI signatures and clinical data to predict survival
Xun Cao, Xi Chen, Zhuo-Chen Lin, Chi-Xiong Liang, Ying-Ying Huang, Zhuo-Chen Cai, Jian-Peng Li, Ming-Yong Gao, Hai-Qiang Mai, Chao-Feng Li, Xiang Guo, Xing Lyu   +11 more
doaj   +1 more source

Early-stage Nasopharyngeal Carcinoma

, 2014
Summary Early-stage nasopharyngeal carcinoma is a highly curable disease. Owing to the high radiosensitivity of nasopharyngeal carcinoma and the small volume of tumor in early-stage disease, definitive radiotherapy alone has been the mainstay of ...
Sze, CKH, Ka On Lam, Lam, KO, Lee, AWM, Anne WM Lee, Henry CK Sze   +5 more
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Nasopharyngeal carcinoma in children [PDF]

Cancer, 1976
Ten children with lymphoepithelioma of the nasopharynx were reviewed. Six had regional spread at presentation and four developed distant metastases. Seven patients are alive, six free of disease. The 5-year survival rate was 62.5% of this series. Five patients presented later with endocrine abnormalities probably related to the radiotherapy; these ...
C H, Fernandez, A, Cangir, N A, Samaan, R, Rivera   +3 more
openaire   +2 more sources

The Prognostic Role of Plasma Epstein-Barr Virus DNA Levels in the Middle of Intensity Modulated Radiation Therapy to Guide Cisplatin Dose Recommendation in Concurrent Chemoradiation Therapy in Patients With Locally Advanced Nasopharyngeal Carcinoma: A Large Cohort Study

Advances in Radiation Oncology, 2022
Purpose: Our purpose was to investigate the prognostic role of plasma Epstein-Barr virus (EBV) DNA levels in the middle of intensity modulated radiation therapy (IMRT).
Zhen-Chong Yang, MD, Chao-Chao Du, PhD, Li-Ting Liu, MD, Yu-Jing Liang, MD, Lin-Quan Tang, MD, Qiu-Yan Chen, MD, Hai-Qiang Mai, MD, PhD, Shan-Shan Guo, MD   +7 more
doaj   +1 more source

Nasopharyngeal carcinoma

Annals of Oncology, 2010
With the improvement in local control achieved by more precise imaging and radiotherapy, the predominant mode of failure for nasopharyngeal carcinoma is distant metastases. Concurrent cisplatin-radiotherapy with or without adjuvant chemotherapy is the standard treatment approach for stages IIB and above disease. The addition of neoadjuvant chemotherapy
openaire   +2 more sources

Establishment of Nasopharyngeal Carcinoma Cell Lines, Patient-Derived Xenografts, and Immortalized Nasopharyngeal Epithelial Cell Lines for Nasopharyngeal Carcinoma and Epstein–Barr Virus Infection Studies

, 2019
Establishment of continuous cell lines and patient-derived xenografts (PDXs) remains a major challenge for nasopharyngeal carcinoma (NPC). All the reported NPC cell lines except one (C666-1) lost their Epstein–Barr virus (EBV) episomes upon long-term ...
W.T. Lin, Yip, YL, W. Deng, Tsang, CM, S.W. Tsao, Deng, W, Tsao, GSW, Y.L. Yip, Lin, W, C.M. Tsang   +9 more
core   +1 more source