Results 51 to 60 of about 846,596 (305)

Integrating oral pre-exposure prophylaxis delivery in primary care family planning clinics: a pragmatic, stepped-wedge, cluster-randomised trial

The Lancet Primary Care
Summary: Background: Integrating pre-exposure prophylaxis (PrEP) delivery in family planning settings might offer an efficient platform to reach women at increased risk for HIV. This study aimed to prospectively assess the effectiveness of a health-care
Kenneth K Mugwanya, MBChB, Daniel Matemo, MPH, Allison Meisner, PhD, Torin Schaafsma, MS, Jennifer Morton, MPH, Cynthia Wandera, BSN, Valarie Kemunto, BSN, Irine Cherotich, MSc, Stephen Odhiambo, Dip, Mercy Bii, Dip, Beatrice Oduor, Dip, Esther Achieng, Dip, Tecy Oyombra, Dip, David Owaga, BSc, Kristin M Beima-Sofie, PhD, ProfMD Jared M Baeten, PhD, John Kinuthia, MMed   +16 more
doaj   +1 more source

Impact of Lockdown on Other National Health Programs [PDF]

Healthline, 2020
Coronavirus outbreak which started by the end of 2019 in Wuhan, an emerging business hub of China killed more than eighteen hundred and infected over seventy thousand individuals within the first fifty days of the epidemic. It turned
N K Goel, Meenu Kalia, R Rohilla
doaj  

Determinants of parental vaccine hesitancy in Canada: results from the 2017 Childhood National Immunization Coverage Survey

BMC Public Health, 2023
Background In 2019, the World Health Organization (WHO) designated vaccine hesitancy as one of the ten leading threats to global health. Vaccine hesitancy exists when vaccination services are available and accessible, but vaccine uptake is lower than ...
Ruoke Chen, Mireille Guay, Nicolas L. Gilbert, Eve Dubé, Holly O. Witteman, Hina Hakim   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Estimation of bed net coverage indicators in Tanzania using mobile phone surveys: a comparison of sampling approaches

Malaria Journal, 2022
Background Threats to maintaining high population access with effective bed nets persist due to errors in quantification, bed net wear and tear, and inefficiencies in distribution activities. Monitoring bed net coverage is therefore critical, but usually
Matt Worges, Benjamin Kamala, Joshua Yukich, Frank Chacky, Samwel Lazaro, Charles Dismas, Sijenun Aroun, Raya Ibrahim, Mwinyi Khamis, Mponeja P. Gitanya, Deodatus Mwingizi, Hannah Metcalfe, Willhard Bantanuka, Sena Deku, David Dadi, Naomi Serbantez, Dana Loll, Hannah Koenker   +17 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A review of programs that targeted environmental determinants of Aboriginal and Torres Strait Islander health [PDF]

, 2013
This review finds that there are relatively few papers describing interventions that target environmental determinants of Indigenous health.Abstract: Objective: Effective interventions to improve population and individual health require environmental ...
Leah Johnston
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source