Results 111 to 120 of about 1,627,853 (314)

National Fraud Initiative

, 2014
The Public Health Agency (PHA) is required by law to protect the public funds it administers. This A4 sheet provides information on the National Fraud Initiative.
openaire   +1 more source

A Citizens Compact: Reaching out to the Citizens of Europe. CEPS EPIN Working Papers No. 14, 1 September 2005 [PDF]

, 2005
[Executive Summary]. How can the deadlock after the ‘no’ to the European Constitutional Treaty in France and the Netherlands be overcome? What should be the aim of the ‘period of reflection’ that has been agreed by the European Council?
Crum, Ben, De Clerck-Sachsse, Julia, de Klauman, Anna, Incerti, Marco, Keohane, Daniel, Koopmann, Martin, Kràl, David., Kurpas, Sebastian, Langdal, Fredrik, Ricard-Nihoul, Gaëtane, Schönlau, Justus, Torreblanca, José I., Vestergaard, Anne Mette   +12 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Implementing the mhGAP-HIG: the process and evaluation of training primary healthcare workers in Khyber Pakhtunkhwa, Pakistan

BJPsych International
Background To address the treatment gap for common mental disorders in low- and middle-income countries facing humanitarian challenges, it is crucial to build the capacity of primary healthcare workers (PHCWs) and integrate mental healthcare into ...
Asma Humayun, Arooj Najmussaqib
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Plant Extract () as a Green Factory for Biofabrication of Gold Nanoparticles

Natural Product Communications, 2015
This work describes a biofabrication process for gold nanoparticles in which the plant extract ( Bupleurum falcatum ) is used as a reducing agent to convert gold ions to gold nanoparticles.
You Jeong Lee, Song-Hyun Cha, Kyoung Jin Lee, Yeong Shik Kim, Seonho Cho, Youmie Park   +5 more
doaj   +1 more source

An Assessment of Cross-National Regulatory Burden Comparisons [PDF]

, 2006
The Article compares several rankings systems for national regulatory compliance costs. It finds the ranking systems are limited to differentiating between those countries least burdened by regulation from those most burdened by regulation.
Hopkins, Thomas D.
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source