Results 101 to 110 of about 1,627,853 (314)

An International Prospectus for Library & Information Professionals: Development, Leadership and Resources for Evolving Patron Needs [PDF]

open access: yes, 2007
The roles of library and information professionals must change and evolve to: 1. accommodate needs of tech-savvy patrons; 2. thrive in the Commons & Library 2.0; 3. provide integrated, just-in-time services; 4. constantly update and enhance technology; 5.
Bailey, D. Russell
core   +1 more source

An Organizational Analysis of Foreign National Prisoners’ Participation Possibilities in Flanders (Belgium) [PDF]

open access: yes, 2020
This mixed-method study first provides insight into the Belgian prison population — particularly foreign national prisoners — based on an analysis of the penal database SIDIS Suite (N = 10,356).
Brosens, Dorien   +4 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network

open access: yesNature Communications, 2017
Hepatic steatosis development may result from dysregulation of lipid metabolism, which is finely tuned by several transcription factors including the PPAR family. Here Kim et al. show that the nuclear receptor RORα inhibits PPARγ-mediated transcriptional
Kyeongkyu Kim   +16 more
doaj   +1 more source

The Global Health interactive Curricula Experience (iCE) Platform & App : Technology that Enables Inter-professional Innovation [PDF]

open access: yes, 2015
Global Health Initiatives Committee (GHIC) Serves the Jefferson community as the premier point of engagement for students & faculty interested in medical and public health issues that transcend national boundaries Creates an institutional focus on ...
Ankeny, Martha Langley, M.Ed.   +7 more
core   +1 more source

The case for metadata harvesting [PDF]

open access: yes, 2004
Metadata harvesting is an increasingly popular model of interaction between the mutually autonomous parties of medium, medium-large federations of digital library services.
ARIIC   +10 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

High resolution melting curve analysis enables rapid and reliable detection of G6PD variants in heterozygous females

open access: yesBMC Genetics, 2018
Background Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon exposure to oxidative stress induced by
Md Tarikul Islam   +23 more
doaj   +1 more source

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