Results 81 to 90 of about 1,627,853 (314)

Open educational resources in Europe: A triptych of actions to support participation in higher education [PDF]

open access: yes, 2006
In contrast to the face-to-face learning of campus based universities and the focus on traditional students, distance teaching universities focus on a mix of distance learning, e-learning, open learning, virtual mobility, learning communities, and the ...
Kirschner, Paul   +3 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

open access: yesNature Communications, 2016
The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte ...
Da-Hye Lee   +13 more
doaj   +1 more source

Chart Accompanying: An Assessment of Cross-National Regulatory Burden Comparisons [PDF]

open access: yes, 2006
The Article compares several rankings systems for national regulatory compliance costs. It finds the ranking systems are limited to differentiating between those countries least burdened by regulation from those most burdened by regulation.
Hopkins, Thomas D.
core   +1 more source

Communication technologies and education: Lessons in the potential of innovation [PDF]

open access: yes, 1997
The evaluation of initiatives in using new forms of technology to enhance teaching and learning will raise awareness of the need for a structured and principled approach to the introduction of innovative methods.
Norman, Nigel
core   +4 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

National patient safety initiatives: Moving beyond what is necessary

open access: yesIsrael Journal of Health Policy Research, 2012
Ilan and Donchin have compared Israel and Canada's experiences in setting a national patient safety agenda. We broaden this comparison to include the U.S.
Zimlichman Eyal, Bates David W
doaj   +1 more source

National Fraud Initiative

open access: yes, 2010
The Public Health Agency is required by law to protect the public funds it administers. This A4 sheet provides information on the National Fraud Initiative.
openaire   +1 more source

Tanzania: Data Strategy And Capacity Building [PDF]

open access: yes, 2017
Tanzania has seen significant improvements to its national development data infrastructure in recent years. In February 2016 the country adopted an Open Data Policy aimed at increasing access to government data and promoting increased transparency and ...

core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

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