Results 91 to 100 of about 9,565,424 (310)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Interest Groups and the Governance of Growth in Organic Farming [PDF]
, 2008 In this paper we probe the issue of developing capacity by exploring the organisational evolution of the key organic interest groups in Australia, the UK and Denmark. A comparison of the Organic Federation of Australia (OFA), the British Soil Association
Daugbjerg, Carsten, Halpin, Darren
core
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Meridiano 47, 2017 O presente artigo busca analisar as principais características intrínsecas à política externa, de maneira geral, e à atuação do diplomata.
Paulo Roberto Almeida
doaj
Limiting political discretion and international environmental policy coordination with active lobbying [PDF]
We address two concerns: trade liberalisation may lead to a race-to-the bottom in environmental standards; supra-national agencies, who might overcome this, may be captured by special interest groups.
Johal, Surjinder, Ulph, Alistair
core
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Gastrodiplomacy: How Indonesian Cuisine Shapes Bilateral Relations with Saudi Arabia (2017-2023)
Jurnal Hubungan InternasionalThis study aims to elucidate Indonesia’s strategic use of gastrodiplomacy in Saudi Arabia from 2017 to 2023, highlighting a soft diplomacy approach. By engaging in gastrodiplomacy, Indonesia intends to introduce its culinary heritage and enhance its ...
Pebria Prakarsa Renta +3 more
doaj +1 more source
Regulations, Market Structure, Institutions, and the Cost of Financial Intermediation [PDF]
This paper examines the impact of bank regulations, market structure, and national institutions on bank net interest margins and overhead costs using data on over 1,400 banks across 72 countries while controlling for bank-specific characteristics.
Asli Demirguc-Kunt +2 more
core