Results 91 to 100 of about 4,328,152 (304)
Materials Research LettersMicrostructural evolution and its mechanical implications in Electron Beam Powder Bed Fusion-manufactured CuCrZr are investigated for conditions: as-built, hot isostatically pressed (HIPped), and after short-term (3 h at different temperatures) and long ...
F. Canillas +5 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Gastrodiplomacy: How Indonesian Cuisine Shapes Bilateral Relations with Saudi Arabia (2017-2023)
Jurnal Hubungan InternasionalThis study aims to elucidate Indonesia’s strategic use of gastrodiplomacy in Saudi Arabia from 2017 to 2023, highlighting a soft diplomacy approach. By engaging in gastrodiplomacy, Indonesia intends to introduce its culinary heritage and enhance its ...
Pebria Prakarsa Renta +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Resolving the National Banking System note-issue puzzle [PDF]
Under the National Banking System, 1863-1914, national banks that deposited sufficient collateral could issue notes provided they paid a tax on notes in circulation: 1 percent per year before 1900 and 1/2 percent thereafter.
Bruce Champ, Neil Wallace
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Afrocentrism, national interest and citizen welfare in Nigeria's foreign policy maneuvers. [PDF]
F1000Res, 2020 Mbara GC, Gopal N.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Integration implementation vector of the national economic interests of Ukraine: theoretical and practical backgrounds aspects [PDF]
International Economic Policy, 2011 In the article there was considered the appropriateness of optimal combining of Ukraine’s economy transparency and policy of economic protectionism for the purpose of its national interest’s defense.
Аndrii Hryshchenko
doaj