Results 91 to 100 of about 85,743,578 (314)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

A changing role for universities in the periphery [PDF]

open access: yes
An international research on interactions between universities and firms is an opportunity to investigate this subject beyond the developed countries.
Márcia Siqueira Rapini   +2 more
core  

RESEARCH UNIVERSITIES IN MALAYSIA: WHAT BEHOLDS? [PDF]

open access: yes, 2017
The National Higher Education Strategic Plan Beyond 2020 aims at further strengthening Malaysian research universities and envisions that two Malaysian universities will be among the Top 100 world universities.
Nooraini Mohamad Sheriff   +1 more
core  

STATE AS AN INVESTOR AND CUSTOMER IN POSTGRADUATE EDUCATION: NATIONAL RESEARCH UNIVERSITIES NETWORK

open access: yesВысшее образование в России, 2022
The article provides an analysis of the state policy as an investor in the course of reforminghigher education system. Here the authors contemplate the problem of underutilization of resources of the network of national research universities by the state
Elena B. Mudrova, Elena B. Vinogradova
doaj  

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Health Research Governance: Introduction of a New Web-based Research Evaluation Model in Iran: One-decade Experience

open access: yesIranian Journal of Public Health, 2016
Background: Governance is one of the main functions of Health Research System (HRS) that consist of four essential elements such as setting up evaluation system.
Reza MALEKZADEH   +13 more
doaj  

PRIORITIES AND PERSPECTIVES OF THE DEVELOPMENT OF THE NATIONAL RESEARCH UNIVERSITY

open access: yesВысшее образование в России, 2022
The article presents the results of the first stage of functioning of Perm Polytechnic University as anational research university in conditions of state support. Priority directions and spheres of NRU activity have been marked out. The goals and perspectives of university development have been outlined.
Anatoly A. Tashkinov   +2 more
openaire   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Fostering national research networks: The case of Turkish coauthorship patterns in the social sciences [PDF]

open access: yes
We analyse the coauthorship networks of researchers affiliated at universities in Turkey by using two databases: the international SSCI database and the Turkish ULAKBIM database. We find that coauthorship networks are composed largely of isolated groups,
Cedric Gossart, Muge Ozman
core  

Research, Analysis and Insight into National Standards (RAINS) Project. Second Report: Understanding New Zealand’s Very Local National Standards [PDF]

open access: yes, 2013
This is the second report of the Research, Analysis and Insight into National Standards (RAINS) project, a three-year study of the introduction of National Standards into New Zealand primary and intermediate ...
Thrupp, Martin
core  

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