A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
A changing role for universities in the periphery [PDF]
An international research on interactions between universities and firms is an opportunity to investigate this subject beyond the developed countries.
Márcia Siqueira Rapini +2 more
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RESEARCH UNIVERSITIES IN MALAYSIA: WHAT BEHOLDS? [PDF]
The National Higher Education Strategic Plan Beyond 2020 aims at further strengthening Malaysian research universities and envisions that two Malaysian universities will be among the Top 100 world universities.
Nooraini Mohamad Sheriff +1 more
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STATE AS AN INVESTOR AND CUSTOMER IN POSTGRADUATE EDUCATION: NATIONAL RESEARCH UNIVERSITIES NETWORK
The article provides an analysis of the state policy as an investor in the course of reforminghigher education system. Here the authors contemplate the problem of underutilization of resources of the network of national research universities by the state
Elena B. Mudrova, Elena B. Vinogradova
doaj
The ubiquitin system in normal and infected germinal center B cells
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Background: Governance is one of the main functions of Health Research System (HRS) that consist of four essential elements such as setting up evaluation system.
Reza MALEKZADEH +13 more
doaj
PRIORITIES AND PERSPECTIVES OF THE DEVELOPMENT OF THE NATIONAL RESEARCH UNIVERSITY
The article presents the results of the first stage of functioning of Perm Polytechnic University as anational research university in conditions of state support. Priority directions and spheres of NRU activity have been marked out. The goals and perspectives of university development have been outlined.
Anatoly A. Tashkinov +2 more
openaire +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Fostering national research networks: The case of Turkish coauthorship patterns in the social sciences [PDF]
We analyse the coauthorship networks of researchers affiliated at universities in Turkey by using two databases: the international SSCI database and the Turkish ULAKBIM database. We find that coauthorship networks are composed largely of isolated groups,
Cedric Gossart, Muge Ozman
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Research, Analysis and Insight into National Standards (RAINS) Project. Second Report: Understanding New Zealand’s Very Local National Standards [PDF]
This is the second report of the Research, Analysis and Insight into National Standards (RAINS) project, a three-year study of the introduction of National Standards into New Zealand primary and intermediate ...
Thrupp, Martin
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