Results 81 to 90 of about 85,743,578 (314)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Library statistics of colleges and universities /

, 1984
Mode of access: Internet.Merged with: Library statistics of colleges and universities. Institutional data, to form: Library statistics of colleges and universities.
National Center for Education Statistics.
core  

Prevalence and stable acquisition of biogenic amine-synthesizing genes in lactic acid bacteria across diverse niches: implications for food safety and human health

npj Science of Food
Biogenic amines (BAs) are metabolites produced by lactic acid bacteria (LAB) with implications for food safety and human health. Despite extensive phenotypic studies on individual BA biosynthesis genes, the distribution, evolutionary dynamics, ecological
Aqib Javaid, Nazia Tabassum, Abirami Karthikeyan, Young-Mog Kim, Won-Kyo Jung, Fazlurrahman Khan   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Multiple Strategies for the Application of Medicinal Plant-Derived Bioactive Compounds in Controlling Microbial Biofilm and Virulence Properties

Antibiotics
Biofilms are complex microbial communities encased within a self-produced extracellular matrix, which plays a critical role in chronic infections and antimicrobial resistance.
Mulugeta Mulat, Riza Jane S. Banicod, Nazia Tabassum, Aqib Javaid, Abirami Karthikeyan, Geum-Jae Jeong, Young-Mog Kim, Won-Kyo Jung, Fazlurrahman Khan   +8 more
doaj   +1 more source

Researcher Engagement At The University And National Library Of Debrecen

, 2018
University Library of Debrecen introduced several research support services to improve researcher engagement. The development of new tools and methods to archive, curate and disseminate the scholarly output of our researchers has been guided not only by the requirements of our scholars and other library patrons, but also by the strengthening presence ...
Gorogh, Edit, Karacsony, Gyongyi, Fazekas-Paragh, Judit   +2 more
openaire   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From ivory tower to factory floor? How universities are changing to meet the needs of industry [PDF]

, 2008
While policy recognises the need to facilitate university-industry technology transfer (UITT), international studies indicate that the setup and effectiveness of the associated instruments is highly context-specific. We examine the reorientation of Irish
PONTIKAKIS Dimitrios, Geoghegan, Will, GEOGHEGAN Will, Pontikakis, Dimitrios   +3 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source