Results 31 to 40 of about 78,970,903 (227)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Root traits for infertile soils [PDF]

, 2013
This work was supported by the Rural and Environment Science and Analytical Services Division (RESAS) of the Scottish Government through Workpackage 3.3 (2011–2016)Crop production is often restricted by the availability of essential mineral elements. For
Alison J. Karley, Lea eWiesel, George, Timothy, Timothy S. George, Philip John White, Dupuy, Lionel, Wishart, Jane, Philip J. White, Jane eWishart, Lionel X. Dupuy, Tracy A. Valentine, Lea Wiesel, White, Philip, Jane Wishart, Valentine, Tracy, Wiesel, Lea, Karley, Alison   +16 more
core   +1 more source

Genotype by environment interaction effect and fresh root yield stability of cassava genotypes under contrasting nitrogen regimes

Scientific Reports
Nitrogen (N) is an important nutrient element needed by cassava for optimum yield and it is a vital component of nucleotides (nucleic acids), enzymes, amino acids (proteins), chlorophyll molecules and hormones, among other essential compounds required ...
Joseph Okpani Mbe, Daniel Dzidzienyo, Simon Peter Abah, Damian Ndubuisi Njoku, Cynhia Idhigu Aghogho, Joseph Onyeka, Pangirayi Tongoona, Chiedozie Egesi   +7 more
doaj   +1 more source

Flowering, Dormancy, Yield Formation and Food Quality in Yam (Dioscorea spp.): Implications for Crop Improvement and Sustainability

Agronomy
Yam is a tuberous crop with great potential for enhancing food security and rural development thus contributing significantly to the lives of people in production areas.
Joy Geraldine Emerald, Paul Ifeanyi Ekeledo, Jude Ejikeme Obidiegwu, Cynthia Adaku Chilaka   +3 more
doaj   +1 more source

Genetic Diversity and Association of Yield-Related Traits in Taro (Colocasia esculenta (L.) Schott) Sourced from Different Agroecological Origins of Nigeria

International Journal of Agronomy, 2023
Taro’s production is characterized by low productivity due to a lack of sufficient improved cultivars suited to the different growing areas coupled with biotic and abiotic stresses.
Tilahun Wondimu Fufa, Happiness Ogba Oselebe, Charles Okechukwu Amadi, Temesgen Matewos Menamo, Wosene Gebreselassie Abtew   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Assessment of Yam mild mosaic virus coat protein gene sequence diversity reveals the prevalence of cosmopolitan and African group of isolates in Ghana and Nigeria

Current Plant Biology, 2020
This study analyzed the genetic diversity of 18 Yam mild mosaic virus (YMMV, genus Potyvirus) isolates collected from field surveys in Ghana (N = 8) and Nigeria (N = 10) in 2012−13.
Chukwuemeka K. Nkere, Emmanuel Otoo, Gabriel I. Atiri, Joseph Onyeka, Gonçalo Silva, Moritz Bömer, Susan E. Seal, P. Lava Kumar   +7 more
doaj   +1 more source

Chromosome evolution and the genetic basis of agronomically important traits in greater yam

Nature Communications, 2022
While greater yam provides food and income security for millions of people around the world, there are limited genomic resources available. Here, the authors report a chromosome-scale assembly of the greater yam genome as well as quantitative trait loci ...
Jessen V. Bredeson, Jessica B. Lyons, Ibukun O. Oniyinde, Nneka R. Okereke, Olufisayo Kolade, Ikenna Nnabue, Christian O. Nwadili, Eva Hřibová, Matthew Parker, Jeremiah Nwogha, Shengqiang Shu, Joseph Carlson, Robert Kariba, Samuel Muthemba, Katarzyna Knop, Geoffrey J. Barton, Anna V. Sherwood, Antonio Lopez-Montes, Robert Asiedu, Ramni Jamnadass, Alice Muchugi, David Goodstein, Chiedozie N. Egesi, Jonathan Featherston, Asrat Asfaw, Gordon G. Simpson, Jaroslav Doležel, Prasad S. Hendre, Allen Van Deynze, Pullikanti Lava Kumar, Jude E. Obidiegwu, Ranjana Bhattacharjee, Daniel S. Rokhsar   +32 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source