Results 41 to 50 of about 38,547 (210)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Genetic Diversity and Association of Yield-Related Traits in Taro (Colocasia esculenta (L.) Schott) Sourced from Different Agroecological Origins of Nigeria

International Journal of Agronomy, 2023
Taro’s production is characterized by low productivity due to a lack of sufficient improved cultivars suited to the different growing areas coupled with biotic and abiotic stresses.
Tilahun Wondimu Fufa, Happiness Ogba Oselebe, Charles Okechukwu Amadi, Temesgen Matewos Menamo, Wosene Gebreselassie Abtew   +4 more
doaj   +1 more source

Popularizing National Root Crops Research Institute (NRCRI) Umudike Innovations amongst Students through the Use of Demonstration Farms

Nigeria Agricultural Journal, 2022
Agricultural innovations will have little or no impact until they are shareed with stakeholders in ways that are meaningful to them. This paper highlights the use of demonstration farm by National Root Crops Research Institute (NRCRI) Umudike to disseminate, promote and popularize her innovations for improved productivity of her mandate crops amongst ...
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Genotype by environment interaction effect and fresh root yield stability of cassava genotypes under contrasting nitrogen regimes

Scientific Reports
Nitrogen (N) is an important nutrient element needed by cassava for optimum yield and it is a vital component of nucleotides (nucleic acids), enzymes, amino acids (proteins), chlorophyll molecules and hormones, among other essential compounds required ...
Joseph Okpani Mbe, Daniel Dzidzienyo, Simon Peter Abah, Damian Ndubuisi Njoku, Cynhia Idhigu Aghogho, Joseph Onyeka, Pangirayi Tongoona, Chiedozie Egesi   +7 more
doaj   +1 more source

Flowering, Dormancy, Yield Formation and Food Quality in Yam (Dioscorea spp.): Implications for Crop Improvement and Sustainability

Agronomy
Yam is a tuberous crop with great potential for enhancing food security and rural development thus contributing significantly to the lives of people in production areas.
Joy Geraldine Emerald, Paul Ifeanyi Ekeledo, Jude Ejikeme Obidiegwu, Cynthia Adaku Chilaka   +3 more
doaj   +1 more source

Assessment of Yam mild mosaic virus coat protein gene sequence diversity reveals the prevalence of cosmopolitan and African group of isolates in Ghana and Nigeria

Current Plant Biology, 2020
This study analyzed the genetic diversity of 18 Yam mild mosaic virus (YMMV, genus Potyvirus) isolates collected from field surveys in Ghana (N = 8) and Nigeria (N = 10) in 2012−13.
Chukwuemeka K. Nkere, Emmanuel Otoo, Gabriel I. Atiri, Joseph Onyeka, Gonçalo Silva, Moritz Bömer, Susan E. Seal, P. Lava Kumar   +7 more
doaj   +1 more source

A dataset of cassava whitefly count images

Data in Brief, 2022
Whiteflies are insect vectors that affect a variety of plants such as tomatoes, cabbages, sweet potatoes, eggplants, and cassava. In Uganda, whiteflies are a major contributor to the spread of Cassava Brown Streak Disease (CBSD).
Joyce Nakatumba-Nabende, Jeremy Francis Tusubira, Claire Babirye, Solomon Nsumba, Christopher Omongo Abu   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Techno-economic analysis of solar photovoltaic system for agricultural pumping irrigation at national root crop research institute, Abia State, Nigeria

ISAE 2025 Proceedings - zbornik radova
This research presents an economic analysis of a 24 kW Solar Photo-voltaic (PV) system tailored for sustainable agricultural irrigation. The proposed system comprises 60 high-efficiency solar panels rated at 400 W each, a modular inverter configuration for power conversion, and supporting infrastructure, including mounting structures, piping, and ...
Johnson Igwe, Uduma Okoro, Igboayaka Ekene   +2 more
openaire   +1 more source