Results 91 to 100 of about 19,191,137 (252)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
, 2010 Milli Mücadele tarihimiz henüz tam olarak bütün yönleriyle ele alınmış değildir. Ancak bilinmektedir ki, bu mücadeleye Anadolu topyekûn katılmıştır ve Karaman kazasının Milli Mücadele'deki rolünü bütünüyle ele alan bir kaynak bulunmamaktadır ...
Gültekin, Tuba
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In search for new Manifesto [PDF]
Sociološki Pregled, 2018 In this paper authors present the new diagnosis of the contemporary 'state of affairs'. To be precise, they look for the emancipation possibilities, bearing in mind the history of class-liberation struggle. Their main thesis, gradually shaped through the
Bratina Boris R., Bratina Oksana A.
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
National Commission on Military, National, and Public Service: Interim Report Executive Summary
, 2019 Executive summary for the interim report of the National Commission on Military, National, and Public Service outlining their charge, findings from information-gathering, and areas for further research, with social media contacts for public ...
United States. National Commission on Military, National, and Public Service.
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Utopia Live: singing the Mozambican struggle for national liberation
Kronos, 2009 This article engages a historical reconstruction of the formation of Makonde revolutionary singing in the process of the Mozambican liberation struggle. The history of 'Utopia live' is here entrusted to wartime genres, marked by heteroglossia and the use
Paolo Israel
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Philosophy Born of Struggle II
, 2019 Patricia Williams presents at 00:00:18; Dorothy Roberts presents at 0:45:00; Peggy Davis presents at 01:02:17.
Philosophy Born of Struggle Conference
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