Results 1 to 10 of about 33,583 (261)
Natriuretic Peptides Regulate Prostate Cells Inflammatory Behavior: Potential Novel Anticancer Agents for Prostate Cancer [PDF]
Biomolecules, 2021 Inflammation, by inducing a tumor-promoting microenvironment, is a hallmark for prostate cancer (PCa) progression. NOD-like receptor protein 3 (NLRP3)-inflammasome activation, interleukin-1β (IL-1β) secretion, and cancer cell-released extracellular ...
Letizia Mezzasoma +3 more
doaj +5 more sources
Cardiac Natriuretic Peptides: Contributors to Cardiac Cachexia or Possible Anti-obesity Agents or Both? [PDF]
Diabetes, 2012 The cardiac natriuretic peptides (NPs) atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are both secreted by the heart in response to myocardial stress and stretch and act via binding to guanylyl cyclase-A (GC-A), with subsequent generation of the second messenger cyclic guanosine monophosphate. GC-A is widely expressed in mammals,
exaly +3 more sources
Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Water and Sodium Metabolism
Frontiers in Pharmacology, 2022 Sodium-glucose cotransporter 2 (SGLT2) inhibitors exert hypoglycemic and diuretic effects by inhibiting the absorption of sodium and glucose from the proximal tubule.
Jun Tang +9 more
doaj +1 more source
Guanylins - Agents with natriuretic effect [PDF]
Biomedical Papers, 2006 Guanylins and uroguanylins are natriuretic peptides with different effects in many of tissues. In context with guanylins, the intestine-renal axis is presented. The overproduction of guanylin or uroguanylin leads to secondary diarrhea with stimulation of Cl(-) secretion.
Pavlina, Solichova +2 more
openaire +2 more sources
Folia Medica Indonesiana, 2021 Cucumber (Cucumis sativus L.). was known for lowering blood pressure agents. Some researches show that Cucumber had a similar mechanism with a loop diuretic (Furosemide), exceeding sodium and potassium excretion.
Vincensa Elicia +2 more
doaj +1 more source
Cardiac function in elderly inpatients in the recovery phase of rehabilitation: determining methods of treatment during the heart failure pandemic [PDF]
Rehabilitacja Medyczna, 2021 Objectives: This study aimed to evaluate cardiac function in elderly inpatients admitted to a recovery phase rehabilitation ward. N-terminal pro-B-type natriuretic peptide (NT-proBNP) was statistically analyzed, along with other laboratory and ...
Hakuo Takahashi
doaj +1 more source
Global Heart, 2021 Background:The Egyptian National Committee of Viral Hepatitis program is the leading national hepatitis C virus (HCV) management program globally. However, limited data is available about the effect of the new directly acting antiviral agents on the ...
Ahmed Farouk Alaarag +2 more
doaj +1 more source
Cardiovascular Safety Reporting in Contemporary Breast Cancer Clinical Trials
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Several cancer therapies have been associated with cardiovascular harm in early‐phase clinical trials. However, some cardiovascular harms do not manifest until later‐phase trials. To limit interdisease variability, we focused on breast cancer.
Arsalan Hamid +11 more
doaj +1 more source
Current Modulation of Guanylate Cyclase Pathway Activity—Mechanism and Clinical Implications
Molecules, 2021 For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention.
Grzegorz Grześk, Alicja Nowaczyk
doaj +1 more source
Circulation, 1968 Amiloride, a new, well-tolerated oral natriuretic and mild diuretic agent, has been evaluated alone and in combination with other diuretics. Its remarkable ability to promote retention rather than loss of potassium makes it a useful adjunct in the management of even the most severe edematous states.
M B, Bull, J H, Laragh
openaire +2 more sources