Results 91 to 100 of about 1,072,475 (388)

Role of musclin in the pathogenesis of hypertension in rat. [PDF]

PLoS ONE, 2013
Musclin is a novel skeletal muscle-derived secretory factor found in the signal sequence trap of mouse skeletal muscle cDNAs. Musclin possesses a region homologous to the natriuretic peptide family.
Ying-Xiao Li, Kai-Chun Cheng, Akihiro Asakawa, Ikuo Kato, Yuki Sato, Haruka Amitani, Namiko Kawamura, Juei-Tang Cheng, Akio Inui   +8 more
doaj   +1 more source

Association of N-terminal pro-brain natriuretic peptide with cognitive function and depression in elderly people with type 2 diabetes [PDF]

, 2012
<p>Background: Type 2 diabetes mellitus is associated with risk of congestive heart failure (CHF), cognitive dysfunction and depression. CHF itself is linked both to poor cognition and depression.
,, Deary, Ian, Feinkohl, Insa, Price, Jackie F., Reynolds, Rebecca M., Sattar, Naveed, Strachan, Mark W. J., Welsh, Paul   +7 more
core   +2 more sources

Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide

Biochemical Journal, 2001
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) exert their physiological actions by binding to natriuretic peptide receptor A (NPRA), a receptor guanylate cyclase (rGC) that synthesizes cGMP in response to both ligands. The family of rGCs is rapidly expanding, and it is plausible that there might be additional, as yet undiscovered,
Oliver Smithies, Joshua W. Knowles, Paula M. Oliver, Nobuyo Maeda, Xun Qian, Peter J. Mohler, Jennifer E. Fox, Michael F. Goy, Kit E. Purdy   +8 more
openaire   +4 more sources

Natriuretic Peptides in Heart Failure [PDF]

Clinical Chemistry, 2014
Heart failure is a major global health problem affecting 23 million people worldwide. As more cardiac patients survive and live longer with this progressive disease, heart failure is a condition for which the prevalence will grow. Based solely on clinical presentation, heart failure can be difficult to diagnose since its presentation is complex, with ...
D.C. Lin, E.P. Diamandis, JL J.r. Januzzi, A. Maisel, A.S. Jaffe, CLERICO, ALDO   +5 more
openaire   +4 more sources

Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes phosphoinositide hydrolysis, Ca2+ release, and activation of protein kinase C

Frontiers in Molecular Neuroscience, 2014
Thus far, three related natriuretic peptides (NPs) and three distinct sub-types of cognate NP receptors have been identified and characterized based on the specific ligand binding affinities, guanylyl cyclase activity, and generation of intracellular ...
K. Pandey
semanticscholar   +1 more source

NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis

Advanced Science, EarlyView.
NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu, Jie Zhang, Hengxing Chen, Haobin Hou, Huanjie Chen, Rongman Xie, Yanlei Chen, Jian Zhang, Dehua Liu, Leping Yan, Rui L. Reis, Joaquim M. Oliveira, Yulong He, Li Zhong, Qinbo Cai, Dongjie Yang   +15 more
wiley   +1 more source

Machine learning-based prediction of elevated N terminal pro brain natriuretic peptide among US general population. [PDF]

ESC Heart Fail
Abstract Aims Natriuretic peptide‐based pre‐heart failure screening has been proposed in recent guidelines. However, an effective strategy to identify screening targets from the general population, more than half of which are at risk for heart failure or pre‐heart failure, has not been well established.
Mori Y, Fukuma S, Yamaji K, Mizuno A, Kondo N, Inoue K.   +5 more
europepmc   +2 more sources

A novel designer natriuretic peptide integrating human C‐type natriuretic peptide, atrial natriuretic peptide, and B‐type natriuretic peptide

The FASEB Journal, 2009
BackgroundThe 17‐amino‐acid (AA) ring of C‐type natriuretic peptide (CNP) is essential for activation of NP receptor (NPR)‐B and the 2nd messenger cGMP. CNP induces minimal hypotension as NPR‐B is more abundantly found in veins vs arteries, but possesses limited renal properties. We designed a novel peptide fusing the CNP ring with AAs from ANP and BNP
John C. Burnett, Candace Y.W. Lee
openaire   +1 more source

Label‐Free Single‐Molecule Immunoassay

Advanced Science, EarlyView.
Label‐free single‐molecule immunoassay (LFSMiA) enables ultra‐sensitive and wide dynamic range protein detection in whole blood samples. LFSMiA features real‐time single‐molecule imaging by plasmonic scattering microscopy, background reduction by a 2‐step sandwich assay, minimizing matrix effect by dynamic tracking of single binding events, and ...
Xiaoyan Zhou, Chao Chen, Shuang Zhou, Guangzhong Ma, Mohammad Javad H. N. Chemerkouh, Christine L. H. Snozek, Eric H. Yang, Jiapei Jiang, Brandyn Braswell, Zijian Wan, Xinyu Zhou, Shaopeng Wang   +11 more
wiley   +1 more source

ANP and BNP responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system. [PDF]

PLoS ONE, 2013
The objectives of this study were to investigate and compare the responses of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in the circulation of hydrated, dehydrated, and dehydrated losartan - treated camels; and to document the ...
Abdu Adem, Mahmoud Al Haj, Sheela Benedict, Javed Yasin, Nicolas Nagelkerke, Fred Nyberg, Tim G Yandle, Chris M Frampton, Lynley K Lewis, M Gary Nicholls, Elsadig Kazzam   +10 more
doaj   +1 more source