Results 21 to 30 of about 1,178,585 (315)

Designer Natriuretic Peptides [PDF]

Journal of Investigative Medicine, 2009
Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects.
Candace Y W, Lee, Hsiao, Lieu, John C, Burnett   +2 more
openaire   +2 more sources

B-type natriuretic peptide predicts long-term prognosis in a cohort of critically Ill patients

Heart International, 2011
B-type natriuretic peptide is an important prognostic marker in heart failure. However, there are limited data for its value in non-cardiac intensive care unit patients, namely regarding long-term prognosis. We investigated the long-term prognostic value
Jorge Pimentel, Eduardo Sousa, Elisabete Jorge, Rui Baptista   +3 more
doaj   +1 more source

Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis

Physiological Reports, 2021
Glomerular podocytes play a key role in proteinuric diseases. Accumulating evidence suggests that cGMP signaling has podocyte protective effects. The major source of cGMP generation in podocytes is natriuretic peptides.
Liming Wang, Yuping Tang, Anne F. Buckley, Robert F. Spurney   +3 more
doaj   +1 more source

N- terminal pro brain natriuratic peptide (nt-probnp) in apparently healthy subjects compared to metabolic syndrome subjects

Advanced Medical Journal, 2022
Background and objectives: B –type natriuretic peptide is synthesized in myocardial cells to respond to increased wall stress in association with heart failure or acute myocardial ischemia.
Zaidan Azeez Hasan, Dhia Mustafa Sulaiman   +1 more
doaj   +1 more source

Effect of Neprilysin Inhibition on Various Natriuretic Peptide Assays.

Journal of the American College of Cardiology, 2019
BACKGROUND With sacubitril/valsartan treatment, B-type natriuretic peptide (BNP) concentrations increase; it remains unclear whether change in BNP concentrations is similar across all assays for its measurement.
Nasrien E Ibrahim, Cian P. McCarthy, S. Shrestha, H. Gaggin, R. Mukai, J. Szymonifka, F. Apple, J. Burnett, Seethalakshmi R. Iyer, J. Januzzi   +9 more
semanticscholar   +1 more source

Effect of natriuretic peptide-guided therapy on hospitalization or cardiovascular mortality in high-risk patients with heart failure and reduced ejection fraction: a randomized clinical trial

Journal of the American Medical Association (JAMA), 2017
Importance The natriuretic peptides are biochemical markers of heart failure (HF) severity and predictors of adverse outcomes. Smaller studies have evaluated adjusting HF therapy based on natriuretic peptide levels (“guided therapy”) with inconsistent ...
G. Felker, K. Anstrom, Kirkwood F. Adams, J. Ezekowitz, M. Fiuzat, N. Houston-Miller, J. Januzzi, Daniel B. Mark, Ileana L. Piña, Gayle Passmore, D. Whellan, Hongqiu Yang, Lawton Cooper, E. Leifer, P. Desvigne‐Nickens, Christopher M. O’Connor   +15 more
semanticscholar   +1 more source

The Effect of Losartan on Plasma Atrial Natriuretic Peptide Levels in the Diabetic Rat Model

Endocrinology Research and Practice, 2022
In creased plasma atrial natriuretic peptide levels accompany the expansion of effective plasma volume in diabetic patients. Atrial natriuretic peptide has a deleterious effect on the pathogenesis of diabetic nephropathy by increasing renal plasma flow ...
Halil Önder Ersöz, Dilek Gogas Yavuz, Osman Özdoğan, Yasemin Budak, Sema Akalın   +4 more
doaj   +2 more sources

Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor

eLife, 2023
Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and pressure, ventricular hypertrophy, fat metabolism, and long bone growth.
Arun Devotta, Hugo Juraver-Geslin, Casey Griffin, Jean-Pierre Saint-Jeannet   +3 more
doaj   +1 more source

Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance

Science Signaling, 2017
Natriuretic peptide receptor C deficiency improves metabolism through signaling in adipose tissue, rather than in skeletal muscle. When fat is more important than muscle Although natriuretic peptides were originally identified as modifiers of blood ...

semanticscholar   +1 more source

Physiology and clinical significance of natriuretic hormones

Indian Journal of Endocrinology and Metabolism, 2013
The natriuretic system consists of the atrial natriuretic peptide (ANP) and four other similar peptides including the wrongly named brain natriuretic peptide (BNP). Chemically they are small peptide hormones predominantly secreted by the cardiac myocytes
Sandeep Chopra, Davis Cherian, Prashant Paul Verghese, Jubbin J Jacob   +3 more
doaj   +1 more source