Results 11 to 20 of about 966,197 (400)

Molecular Implications of Natriuretic Peptides in the Protection from Hypertension and Target Organ Damage Development [PDF]

International Journal of Molecular Sciences, 2019
The pathogenesis of hypertension, as a multifactorial trait, is complex. High blood pressure levels, in turn, concur with the development of cardiovascular damage.
S. Rubattu, Maurizio Forte, S. Marchitti, M. Volpe   +3 more
semanticscholar   +3 more sources

Natriuretic Peptides in the Management of Solid Organ Transplantation Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis [PDF]

International Journal of Nephrology, 2013
Randomized controlled trials involving natriuretic peptide administration in solid organ transplantation setting have shown inconsistent effects for renal endpoints. We conducted a systematic review and meta-analysis of these trials to ascertain the role
Sagar U. Nigwekar, Hrishikesh Kulkarni, Charuhas V. Thakar   +2 more
doaj   +4 more sources

Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis [PDF]

The Lancet Diabetes and Endocrinology, 2016
BACKGROUND: Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable ...
Natriuretic Peptides Studies Collaboration, P. Willeit, S. Kaptoge, P. Welsh, A. Butterworth, Rajiv Chowdhury, Sarah Spackman, L. Pennells, P. Gao, S. Burgess, Daniel F. Freitag, M. Sweeting, A. Wood, N. Cook, S. Judd, S. Trompet, Vijay Nambi, M. Olsen, Brendan M. Everett, F. Kee, J. Ärnlöv, V. Salomaa, D. Levy, J. Kauhanen, J. Laukkanen, M. Kavousi, T. Ninomiya, J. Casas, L. Daniels, L. Lind, C. Kistorp, J. Rosenberg, T. Mueller, S. Rubattu, D. Panagiotakos, O. Franco, James de Lemos, A. Luchner, J. Kizer, S. Kiechl, J. Salonen, S. Goya Wannamethee, Rudolf A de Boer, B. Nordestgaard, J. Andersson, T. Jørgensen, O. Melander, C. Ballantyne, C. Defilippi, P. Ridker, M. Cushman, W. Rosamond, S. Thompson, V. Gudnason, N. Sattar, J. Danesh, E. di Angelantonio   +56 more
semanticscholar   +3 more sources

Molecular Mechanism of Blood Pressure Regulation through the Atrial Natriuretic Peptide

Biology, 2022
Natriuretic peptides, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), have cardioprotective effects and regulate blood pressure in mammals.
Takeshi Tokudome, Kentaro Otani
doaj   +1 more source

The Importance of Natriuretic Peptides in Cardiometabolic Diseases

Journal of the Endocrine Society, 2020
The natriuretic peptide (NP) system is composed of 3 distinct peptides (atrial natriuretic peptide or ANP, B-type natriuretic peptide or BNP, and C-type natriuretic peptide or CNP) and 3 receptors (natriuretic peptide receptor-A or NPR-A or particulate ...
Shravya Vinnakota, Horng H. Chen
semanticscholar   +1 more source

Role of natriuretic peptides in the assessment of aortic stenosis severity [PDF]

Vojnosanitetski Pregled, 2010
Background/Aim. Symptom onset is a critical point in natural course of aortic stenosis and the most important indication for aortic valve replacement.
Davičević Žaklina, Tavčiovski Dragan, Matunović Radomir, Vukotić Snježana, Mijailović Zdravko   +4 more
doaj   +1 more source

A novel natriuretic peptide [PDF]

BMC Pharmacology, 2011
Background Receptors for the natriuretic peptides (NPs) ANP, BNP and CNP are highly expressed in lung, suggesting that this organ is an important physiological target for NP signalling. By stimulating vasoand bronchodilation and inhibiting cell proliferation and fibrotic processes, NPs may have therapeutic potential in various lung diseases. Mechanisms
Ralf Middendorff, Fritz Buck, Dieter Müller, Hanna Höfeld   +3 more
openaire   +2 more sources

Natriuretic Peptide-Based Novel Therapeutics: Long Journeys of Drug Developments Optimized for Disease States

Biology, 2022
The field of natriuretic peptides (NPs) as an endocrine hormone has been developing since 1979. There are three peptides in humans: atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), which bind to the guanylyl cyclase-A (GC-A ...
Tomoko Ichiki, Atsushi Jinno, Yoshihisa Tsuji   +2 more
doaj   +1 more source

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides. [PDF]

ESC Heart Fail
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Berthelot E, Laouar T, Beurnier A, Hrynchynshyn N, Eicher JC, Tartière JM, Jourdain P, Lairez O, Gellen B.   +8 more
europepmc   +2 more sources

Natriuretic peptides and cardiovascular damage in the metabolic syndrome. Molecular mechanisms and clinical implications [PDF]

, 2010
Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and natriuretic properties ...
ALONZO, ALESSANDRO, Rossi C, RUBATTU, Speranza Donatella, SAVOIA, Carmine, VOLPE, Massimo   +4 more
core   +1 more source