Results 51 to 60 of about 16,453,131 (296)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Town of Hampton Stormwater Management PREP Natural Resources Outreach Coalition Grant Final Project Report [PDF]
, 2010 PREP provided $3,500 towards the project which was matched by municipal funds to pay for consulting advice on improving the regulations. The Planning Board provided exceptional in-kind match on the project, with many hours of work spent by a volunteer ...
Natural Resources Outreach Coalition +1 more
core +2 more sources
Manufacturing Of Robust Natural Fiber Preforms Utilizing Bacterial Cellulose as Binder [PDF]
, 2014 We present a novel method of manufacturing rigid and robust short natural fiber preforms using a papermaking process. Bacterial cellulose acts simultaneously as the binder for the loose fibers and provides rigidity to the fiber preforms.
Bismarck, A +3 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Ethiopian Journal of Science and Sustainable DevelopmentThe key properties of concrete are often controlled using synthetic admixtures, despite their possible adverse environmental effects. This study tested the potential of Opuntia ficus-indica (OFI) liquid mucilage as a natural and sustainable concrete ...
Besrat Berhanu +1 more
doaj +1 more source
Why frequencies are natural [PDF]
, 2007 Research in mathematical cognition has shown that rates, and other interpretations of x/y, are hard to learn and understand. On the other hand, there is extensive evidence that the brain is endowed with a specialized mechanism for representing and ...
Butterworth, B
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source