Results 201 to 210 of about 18,013 (253)
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The antithrombotic activity of natural and synthetic coumarins
Fitoterapia, 2021Thrombosis, which seriously endangers human health and life, is the leading cause of morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and development of thrombotic diseases and play an important role in the treatment of thrombotic diseases.
Leilei, Gao +5 more
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Natural and synthetic coumarins as antileishmanial agents: A review
European Journal of Medicinal Chemistry, 2020The neglected tropical disease leishmaniasis is still a major public health problem that affects millions of people worldwide. Related to poor-living conditions, this vector-borne disease presents multiple clinical manifestations - from asymptomatic to systemic conditions.
Guilherme Arraché, Gonçalves +6 more
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Synthetic and Natural Coumarins as Antioxidants
Mini-Reviews in Medicinal Chemistry, 2006Coumarins, an old class of compounds, are naturally occurring benzopyrene derivatives. A lot of coumarins have been identified from natural sources, especially green plants. These natural compounds have served as valuable leads for further design and synthesis of more active analogs.
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Natural oxyprenylated coumarins are modulators of melanogenesis
European Journal of Medicinal Chemistry, 2018Naturally occurring coumarins 7-isopentenyloxycoumarin, auraptene, and umbelliprenin are able to modulate the biosynthesis of melanin in murine Melan-a cells probably through the interaction with selected biological targets like estrogen receptor β and aryl hydrocarbon receptor.
Fiorito S +7 more
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Natural Coumarins as a Novel Class of Neuroprotective Agents
Mini-Reviews in Medicinal Chemistry, 2009Neurodegenerative disorders are a heterogeneous group of diseases and are among the most invaliding syndromes for humans. The aim of this manuscript is to review what has been reported so far in the literature about coumarins as a novel class of pharmacologically active compounds in chemoprevention and/or therapy of these diseases.
EPIFANO, Francesco +3 more
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Progress in the Chemistry of Naturally Occurring Coumarins
2017Coumarins are the largest group of 1-benzopyran derivatives found in plants. The initial member of this group of compounds, coumarin (2H-1-benzopyran-2-one), a fragrant colorless compound, was first isolated from the Tonka bean (Dipteryx odorata, family Fabaceae) in 1820. The name coumarin comes from a French term for the tonka bean, coumarou.
Satyajit D, Sarker, Lutfun, Nahar
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1952
It is striking that apart from coumarin, hydrocoumarin, and dicoumarol, all naturally occurring coumarins have an oxygen atom at the 7-position i. e. they can be regarded as derivatives of umbelliferone, which is one of the most widely distributed compounds of this class.
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It is striking that apart from coumarin, hydrocoumarin, and dicoumarol, all naturally occurring coumarins have an oxygen atom at the 7-position i. e. they can be regarded as derivatives of umbelliferone, which is one of the most widely distributed compounds of this class.
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Synthesis of Analogues of Natural Coumarins and Coumarinolignans
Russian Journal of Bioorganic Chemistry, 20053-Aryl-4H-coumarins with the 1,3-benzodioxol, 1,4-benzodioxane, and 1,5-benzodioxepane moieties were synthesized by modified methods. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2005, vol. 31, no. 3; see also http://www.maik.ru.
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Synthetic and Natural Coumarins as Cytotoxic Agents
Current Medicinal Chemistry-Anti-Cancer Agents, 2005Coumarins, an old class of compounds, are naturally occurring benzopyrene derivatives. A lot of coumarins have been identified from natural sources, especially green plants. The pharmacological and biochemical properties and therapeutic applications of simple coumarins depend upon the pattern of substitution.
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The field ionization spectra of some natural coumarins
Biological Mass Spectrometry, 1974The field ionization and electron impact mass spectra of eleven coumarins have been compared. In the field ion spectra the molecular ions were the base peaks and structurally diagnostic fragment ions formed by direct cleavage were present, whereas the molecular ions were weak in the electron impact spectra and fragment ions formed by rearrangement were
D E, Games +3 more
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