Results 71 to 80 of about 1,193,354 (264)

Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery

Drug Delivery, 2018
Therapeutic outcome for the treatment of glioma was often limited due to the two barriers involved: the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability
Lin Cui, Yuli Wang, Meng Liang, Xiaoyang Chu, Shiyao Fu, Chunsheng Gao, Qianqian Liu, Wei Gong, Meiyan Yang, Zhiping Li, Lian Yu, Chunrong Yang, Zhide Su, Xiangyang Xie, Yang Yang, Chunsheng Gao   +15 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A demo-genetic model shows how silviculture reduces natural density-dependent selection in tree populations. [PDF]

Evol Appl, 2023
Godineau C, Fririon V, Beudez N, de Coligny F, Courbet F, Ligot G, Oddou-Muratorio S, Sanchez L, Lefèvre F.   +8 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Determinação da Distância de Dispersão Efetiva de Cabralea canjerana

Floresta e Ambiente
Objetivou-se conhecer a distância de dispersão efetiva de Cabralea canjerana (Vell.) Mart. em um fragmento de Floresta Estacional. Foram alocadas parcelas de 5 m × 5 m em uma área com alta densidade de indivíduos regenerantes da espécie.
Anna Paula Lora Zimmermann, Frederico Dimas Fleig, Gabriel Paes Marangon   +2 more
doaj   +1 more source

Lewis Structures from Open Quantum Systems Natural Orbitals: Real Space Adaptive Natural Density Partitioning. [PDF]

J Phys Chem A, 2021
Francisco E, Costales A, Menéndez-Herrero M, Pendás ÁM.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effect of agricultural practices on mycorrhizal diversity and abundance in winter wheat fields of Khorasan province

پژوهشهای زراعی ایران, 2009
As a part of soil biodiversity, mycorrhiza has an important role on soil function. For assessment of agricultural practices on spore density and diversity of mycorrhiza, a study was conducted in winter wheat fields on Shirvan, Mashhad and Gonabad, three ...
alireza koochaki, parviz rezvani moghadam, amir lakziyan, mehdi nassiri mahalati   +3 more
doaj   +1 more source