Results 61 to 70 of about 8,265,428 (297)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Social and demographic effects of anthropogenic mortality: a test of the compensatory mortality hypothesis in the red wolf. [PDF]
PLoS ONE, 2011 Whether anthropogenic mortality is additive or compensatory to natural mortality in animal populations has long been a question of theoretical and practical importance.
Amanda M Sparkman +2 more
doaj +1 more source
NATURAL SELECTION AND DENSITY-DEPENDENT POPULATION GROWTH
Genetics, 1983 ABSTRACT Natural selection was studied in the context of density-dependent population growth using a single locus, continuous time model for the rates of change of population size and allele frequency. The maximization principle of density-dependent selection was applied to a class of fitness expressions with explicit recruitment and ...
R A, Desharnais, R F, Costantino
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Journal of Natural FibersFiber density can be used to estimate composite weight and to evaluate fiber content for property predictions in fiber-reinforced composites. Yet, natural fibers don’t have fixed density value given on datasheet and their density measurement is affected ...
Abebayehu Abdela +4 more
doaj +1 more source
Diagnostyka, 2023 The main novelty of the paper is that analytical, experimental, and numerical analyses are used to investigate the free vibration problem of a sandwich structure in which Nanocomposites skins (SiO2/epoxy and Al2O3/epoxy) at different densities are used ...
Marwan Al-Shablle +3 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Natural variables for density functionals
Physical Review A, 1997 Various energy functionals in density-functional theory must possess the form of ^b f (z , h ,j1 ,j2 ,. . . ,jn)&, if one assumes that they can be expressed as ^g(l ,r,r(r),r ,r , . . . ,r )&. Here r(r) and r (m) are the electron density and its mth-order gradient; f and g are proper analytic functions of their variables; m is 2 when the functionals ...
openaire +2 more sources