Results 81 to 90 of about 9,712,563 (292)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Microbial membrane transport genes in maize rhizosphere under fertilization – a preliminary study

Scientific Reports
Microbial DNA fragments isolated from maize rhizosphere soil under different soil fertilization treatments were sequenced, and the analysed genes contained membrane transport genes for the uptake and utilization of various substrates, nutrients ranging ...
Matthew Chekwube Enebe, Olubukola Oluranti Babalola   +1 more
doaj   +1 more source

Study of Viral Coinfection of the Ixodes persulcatus Ticks Feeding on Humans in a Natural Focus of the South of the Far East. [PDF]

Microorganisms, 2023
Leonova GN, Somova LM, Abramova SA, Pustovalov EV.   +3 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

On natural focus of Leptosperous infection in Tajikistan

Agricultural Technologies, 2019
As a result of the previous researches (in 2010-2018) we managed to reveal the natural and anthropurgic sources of leptospirosis distribution in Tajikistan and identify the most frequently circulating leptospira serotypes among wild animals; we identified the main sources of natural and anthropurgic foci and determined the occurrence of certain ...
Orzugul D. Nazarova, Abdukarim A. Muminov, Shuhrat N. Jumaev   +2 more
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Biochar soil amendments affect mycorrhizal colonization, root nodulation and dry matter accumulation in cowpeas (Vigna unguiculata (L.) Walp.)

Studia Universitatis Babeș-Bolyai. Biologia
There is increasing demand for renewable inputs to improve soil productivity to satisfy the ever-growing human population. Biochar as a renewable resource has attracted attention over the years as soil amendment, notable for climate change mitigation and
Ifeyinwa Monica UZOH, Keabetswe Chriscellda RAMADILE, Uchechukwu Paschal CHUKWUDI, Ozede Nicholas IGIEHON, Akinlolu Olalekan AKANMU, Olubukola Oluranti BABALOLA   +5 more
doaj   +1 more source