Results 111 to 120 of about 1,685,324 (346)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Changes in the food supply capacity of alpine grassland ecosystem: A dialectic synthesis of natural and anthropogenic drivers

Advances in Climate Change Research, 2020
Grassland-based animal husbandry and livestock production is the main contributor to livelihood creation for herdsmen. By using the structural dynamics method, this study quantified the changes in the food supply capacity (FSC) of alpine grassland ecosystem and sensitivity to significant variables.
openaire   +2 more sources

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Ecosystem services in the Northern Tianshan Urban Agglomeration: Nonlinear responses to natural and human factors and threshold-based spatial optimization strategies

Journal of Hydrology: Regional Studies
Study Region: The Northern Tianshan Urban Agglomeration, an oasis-dominated corridor along the northern foothills of the Tianshan Mountains in arid north-west China, combines alpine catchments, irrigated plains, and rapidly expanding cities.
Ying Meng, Weixin Du, Li Chen, Zhigang Zhao, Haiyan Du, Zhipeng Li, Mengjie Song, Shala Tuohetaerhan   +7 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Large-Scale Modelling of Global Food Security and Adaptation under Crop Yield Uncertainty [PDF]

Concerns about future food security in the face of volatile and potentially lower yields due to climate change have been at the heart of recent discussions on adaptation strategies in the agricultural sector.
Fuss, Sabine, Havlik, Petr, Obersteiner, Michael, Schmid, Erwin, Szolgayova, Jana   +4 more
core   +1 more source

Operation Analysis of Refrigerated Display Cabinets Based on Thermal Energy Storage and Cooling Using Natural Cold Source

Zhileng xuebao, 2023
In this study, a simulation model of a natural cold source-based refrigerated display cabinet system is established by using the TRNSYS software. First, the air supply temperature of the display cabinet and the cooling temperature of the coolant are ...
Yuan Pei, He Zhengyang, Liu Aolong, Hou Feng, L, Yanli   +5 more
doaj  

Urban Food Supply Chain Resilience for Crises Threatening Food Security: A Qualitative Study.

Journal of the Academy of Nutrition and Dietetics, 2019
BACKGROUND Businesses and organizations involved in growing, distributing, and supplying food may face severe disruptions from natural and human-generated hazards, ranging from extreme weather to political unrest.
A. Hecht, E. Biehl, D. Barnett, R. Neff
semanticscholar   +1 more source

Poverty alleviation among fishermen within the floodplains of Kaduna River: implication for introducing commercial fish farming at village level in Doko local government area of Niger State, Nigeria [PDF]

, 2005
A diagnostic survey was conducted among the fishermen in six selected villages in Doko Local Government Area of Niger State. One hundred and fifty fishermen were randomly selected and interviewed to find out whether or not they had interest in commercial
Gana, F.S., Yaro, I.
core  

Future agriculture and food supply chain - not even doomsday preppers got it right [PDF]

, 2017
Future agriculture and food supply chain is one of the pillars of human survival and prosperity in the long run. The planet’s ecosystem is very fragile and influenced by a large array of very diverse natural and human factors which are frequently ...
Stefanic, Filip, Stefanic, Ivan
core   +2 more sources