Results 31 to 40 of about 643,109 (294)

Unheard and Under‐Supported: Health‐Related Quality of Life in Children, Adolescents, and Young Adults With Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia, Giulia Reggiani, Elizabeth J. Maran, Maria Elisa Delle Fave, Ilaria Baido, Anna Chiara Frigo, Maria Paola Boaro, Raffaella Colombatti   +7 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Hydro-mechanical effects of deciduous forest on slope stability: First results from a case study in Western Norway [PDF]

E3S Web of Conferences
The use of vegetation as a nature-based solution for shallow landslide risk reduction is receiving increased attention in the scientific community, as plants can provide hydro-mechanical reinforcement of slopes.
DiBiagio Amanda, Capobianco Vittoria, Oen Amy, Tallaksen Lena M.   +3 more
doaj   +1 more source

Systematic human rights violations, traumatic events, daily stressors and mental health of Rohingya refugees in Bangladesh

Conflict and Health, 2020
Background Almost 900,000 Rohingya refugees currently reside in refugee camps in Southeastern Bangladesh. Prior to fleeing Myanmar, Rohingya experienced years of systematic human rights violations, in addition to other historical and more recent ...
Andrew Riley, Yasmin Akther, Mohammed Noor, Rahmat Ali, Courtney Welton-Mitchell   +4 more
doaj   +1 more source

Long-term impacts of tropical storms and earthquakes on human population growth in Haiti and the Dominican Republic [PDF]

, 2011
Since the 18th century, Haiti and the Dominican Republic have experienced similar natural forces, including earthquakes and tropical storms. These countries are two of the most prone of all Latin American and Caribbean countries to natural hazards events,
Christian D. Klose, Christian Webersik
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Natural Hazard Overview: Wind [PDF]

, 2018
The National Centre for Resilience supported the Met Office and their partner organisations in the production of a set of Natural Hazard Overviews. This factsheet is one of the set commissioned to meet a requirement for Scotland-specific information ...
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core  

Research and Development of Immersive Computational Thinking Tools using Virtual Reality, Natural Hazards Data, and Scientific Visualization to Engage K-12 Students in Scientific Computing and Engineering Education [PDF]

, 2019
The NHERI DesignSafe-CI Research Experience for Teachers (RET) supplement recruits two high school teachers to work alongside faculty, researchers, and staff of the Texas Advanced Computing Center (TACC) at The University of Texas at Austin.
Garza, Edgar, Marquez, Jessica, Van Houten, Katrina   +2 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source