Results 31 to 40 of about 155,311 (219)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Assessing the Fire-Modified Meteorology of the Grassland and Forest Intersection Zone in Mongolia Using the WRF-Fire Model

Fire, 2023
Climate change is already significantly affecting the frequency of wildfires in most regions of the world, and the risk of wildfires is expected to amplify further with global warming.
Yongli Wang, Lamei Shi, Zitong Shi, Qichao Yao, Zhou Wang, Linhao Zhong   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The potential use of nature-based solutions as natural hazard mitigation measure for linear infrastructure in the Nordic Countries

Geoenvironmental Disasters
Background Reliable infrastructure is vital for Nordic societies, but they face escalating climate risks. Climate change is increasing magnitude and frequency of floods, storms, and landslides, making adaptive solutions crucial.
Vittoria Capobianco, Rosa Maria Palau, Anders Solheim, Kjersti Gisnås, Graham Gilbert, Per Danielsson, Peter van der Keur   +6 more
doaj   +1 more source

Systematic human rights violations, traumatic events, daily stressors and mental health of Rohingya refugees in Bangladesh

Conflict and Health, 2020
Background Almost 900,000 Rohingya refugees currently reside in refugee camps in Southeastern Bangladesh. Prior to fleeing Myanmar, Rohingya experienced years of systematic human rights violations, in addition to other historical and more recent ...
Andrew Riley, Yasmin Akther, Mohammed Noor, Rahmat Ali, Courtney Welton-Mitchell   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Construction and Application of an Emergency Monitoring Indicator Evaluation Model Based on the Spatiotemporal Evolution of Forest Fires

Fire
The lack of scientific methods for selecting monitoring indicators and equipment undermines the efficiency of forest fire emergency response. To address this gap, we developed a novel evaluation model for emergency monitoring indicators based on the ...
Jikun Liu, Chenghu Wang, Guiyun Gao, Yiyu Wang   +3 more
doaj   +1 more source