Results 51 to 60 of about 4,381,528 (386)
Incidence, prevalence, and natural history of primary sclerosing cholangitis in the United Kingdom
Medicine, 2017 Primary sclerosing cholangitis (PSC) is a rare obliterative fibrotic condition of the bile ducts. We assessed PSC epidemiology and natural history within the UK Clinical Practice Research Datalink (CPRD).
Huifang Liang +4 more
semanticscholar +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Natural History: the sense of wonder, creativity and progress in ecology
Scientia Marina, 2001 This essay addresses the question of blending natural history and ecological wisdom into the genuine creativity exemplified by Prof. Ramon Margalef. Many have observed that modern biology is a triumph of precision over accuracy, and that ecology has ...
Paul K. Dayton, Enric Sala
doaj +1 more source
Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study From Turkey
The Journal of Clinical Endocrinology & Metabolism, 2016 Context: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by near-total lack of body fat. Objective: We aimed to study natural history and disease burden of various subtypes of CGL.
TUYSUZ, B +26 more
openaire +6 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Interpretation of evolution as part of science popularization in natural history museums
Geo&Bio, 2021 The paper presents a brief review of the scientific and educational role of natural history museums, particularly in the field of interpretation of organic evolution.
Z. Barkaszi, O. Kovalchuk, A. Maliuk
doaj +1 more source
Robert Boyle and the early Royal Society: a reciprocal exchange in the making of Baconian science [PDF]
, 2007 This paper documents an important development in Robert Boyle's natural-philosophical method – his use from the 1660s onwards of ‘heads’ and ‘inquiries’ as a means of organizing his data, setting himself an agenda when studying a subject and soliciting ...
Hunter, Michael
core +1 more source
Building Next-Generation Collections: Natural History Specimens, Just One Click Away! [PDF]
Biodiversity Information Science and Standards, 2018 Digitisation has made significant advances in many natural history collections since the 1980s. The Vertebrate Zoology Collections team of the Canadian Museum of Nature (CMNVZC; ca. 1,250,000 catalogued specimens) has the ambition to go fully digital with our physical objects and associated data.
Khidas,Kamal, Tessier,Stéphanie
openaire +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source