Results 281 to 290 of about 409,451 (306)

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

Advanced Science, EarlyView.
To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan, Chunrong Yang, Zhongliang Fu, Yuchen Yang, Ying Zhuo, Hongwei Hou, Jinghong Li   +6 more
wiley   +1 more source

Modeling human natural killer cell development and drug response in a microfluidic bone marrow model. [PDF]

Front Immunol
Koenig L, Ben-Eliezer I, Tao TP, Winter A, Grossman M.   +4 more
europepmc   +1 more source

Germline natural killer cell receptors modulating the T cell response. [PDF]

Front Immunol
Mora-Bitria L, Asquith B.
europepmc   +1 more source

Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer. [PDF]

Signal Transduct Target Ther
Wei C, Liao K, Chen HJ, Xiao ZX, Meng Q, Liu ZK, Lu YX, Sheng H, Mo HY, Wu QN, Han Y, Zeng ZL, Guan XY, Luo HY, Ju HQ, Xu RH.   +15 more
europepmc   +1 more source

Impaired natural killer cell maturation in lung adenocarcinoma driven by <i>FABP4</i> and <i>SPON2</i> downregulation through disrupted lipid metabolism. [PDF]

Transl Lung Cancer Res
Tian H, Li K, Chen J, Guo W, Guo Z, Zhang S, Xie Z, Huang X, Wu S, Zhong W.   +9 more
europepmc   +1 more source

Primary intestinal T-cell and natural killer-cell lymphomas: Clinicopathologic and prognostic features of 79 cases in South China. [PDF]

Am J Clin Pathol
Guo N, Zhou C, Wang Y, Fu J, Chen Y, Wang F, Rao H.   +6 more
europepmc   +1 more source

The Golgi complex governs natural killer cell lytic granule positioning to promote directionality in cytotoxicity. [PDF]

Cell Rep
Pedroza LA, van den Haak F, Frumovitz A, Hernandez E, Hegewisch-Solloa E, Orange TK, Sheehan KB, Prockop S, Bodansky A, Chinn IK, Lupski JR, Posey JE, Mace EM, Li Y, Orange JS.   +14 more
europepmc   +1 more source

Targeting Caveolin-1 in Multiple Myeloma Cells Enhances Chemotherapy and Natural Killer Cell-Mediated Immunotherapy. [PDF]

Adv Sci (Weinh)
Zhan D, Du Z, Zhang S, Huang J, Zhang J, Zhang H, Liu Z, Menu E, Wang J.   +8 more
europepmc   +1 more source

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Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders

Nature Reviews Drug Discovery, 2022
Nicholas A Maskalenko, Dmitry Zhigarev, Kerry S Campbell   +2 more
exaly