Results 21 to 30 of about 749,043 (396)

Natural Killer T and Natural Killer Cell-Based Immunotherapy Strategies Targeting Cancer

Biomolecules, 2023
Both natural killer T (NKT) and natural killer (NK) cells are innate cytotoxic lymphoid cells that produce inflammatory cytokines and chemokines, and their role in the innate immune response to tumors and microorganisms has been investigated. Especially,
Tomonori Iyoda, Satoru Yamasaki, Shogo Ueda, Kanako Shimizu, Shin-ichiro Fujii   +4 more
doaj   +1 more source

The activating receptors 2B4 and NTB-A, but not CRACC are subject to ligand-induced down-regulation on human natural killer cells [PDF]

, 2010
Activation of natural killer cells can be mediated by different receptors. Stimulation of the receptors 2B4, NTB-A and CRACC, members of the SLAM-related receptor family, induces cytotoxicity and cytokine production.
Carolin Böhm, Carsten Watzl, Carsten Watzl, Sibel Durlanik, Stephan Meinke   +4 more
core   +2 more sources

Natural Killer Cell Memory [PDF]

Immunity, 2015
Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of
Joseph C. Sun, Joseph C. Sun, Lewis L. Lanier, Timothy E. O’Sullivan   +3 more
openaire   +5 more sources

Deciphering Natural Killer Cell Homeostasis

Frontiers in Immunology, 2020
Natural killer (NK) cells have a central role within the innate immune system, eliminating virally infected, foreign and transformed cells through their natural cytotoxic capacity.
Aline Pfefferle, Benedikt Jacobs, Benedikt Jacobs, Alvaro Haroun-Izquierdo, Lise Kveberg, Lise Kveberg, Ebba Sohlberg, Karl-Johan Malmberg, Karl-Johan Malmberg, Karl-Johan Malmberg   +9 more
doaj   +1 more source

Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT

Nature Communications, 2022
Natural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell ...
Yoav Charpak-Amikam, Tom Lapidus, Batya Isaacson, Alexandra Duev-Cohen, Tal Levinson, Adi Elbaz, Francesca Levi-Schaffer, Nir Osherov, Gilad Bachrach, Lois L. Hoyer, Maya Korem, Ronen Ben-Ami, Ofer Mandelboim   +12 more
doaj   +1 more source

Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]

, 2012
Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Bower, Mark, Gazzard, Brian G, Goodier, Martin R, Gregson, John NS, Kuri-Cervantes, Leticia, Mela, Christopher M   +5 more
core   +1 more source

Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation

Frontiers in Immunology, 2017
Natural killer (NK) cells are a promising tool for the use in adoptive immunotherapy, since they efficiently recognize and kill tumor cells. In this context, ex vivo cultivation is an attractive option to increase NK cells in numbers and to improve their
Markus Granzin, Evelyn Ullrich, Evelyn Ullrich, Juliane Wagner, Juliane Wagner, Ulrike Köhl, Adelheid Cerwenka, Adelheid Cerwenka, Volker Huppert   +8 more
doaj   +1 more source

Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells

Haematologica, 2016
Natural killer cells are key cells of the innate immune system. Natural killer cell receptor repertoires are diversified by a stochastic expression of killer-cell-immunoglobulin-like receptors and lectin-like receptors such as NKG2 receptors.
Loredana Ruggeri, Elena Urbani, Pascale André, Antonella Mancusi, Antonella Tosti, Fabiana Topini, Mathieu Bléry, Lucia Animobono, François Romagné, Nicolai Wagtmann, Andrea Velardi   +10 more
doaj   +1 more source

Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia [PDF]

, 2017
Interactions between killer-immunoglobulin-like receptors (KIRs) and their HLA class I ligands are instrumental in natural killer (NK) cell regulation and protect normal tissue from NK cell attack.
Aurelius, J., Bernson, E., Brune, M., Foà, R., Hallner, A., Hellstrand, K., Kiffin, R., Martner, A., Rydström, A., Sander, F. E., Thorén, F. B., Werlenius, O., Wilsson, O.   +12 more
core   +1 more source

Natural killer cell-based immunotherapy for acute myeloid leukemia

Journal of Hematology & Oncology, 2020
Despite considerable progress has been achieved in the treatment of acute myeloid leukemia over the past decades, relapse remains a major problem. Novel therapeutic options aimed at attaining minimal residual disease-negative complete remission are ...
Jing Xu, T. Niu
semanticscholar   +1 more source