Results 221 to 230 of about 425,656 (354)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes [PDF]

Yuxiu Xu, Xin Li, Fang Cheng, Bao Zhao, Min Fang, Zihai Li, Songdong Meng   +6 more
openalex   +1 more source

A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE₂-mediated immunosuppression and inhibits breast cancer metastasis [PDF]

, 2013
Xinrong Ma, Dawn Holt, Namita Kundu, Jocelyn Reader, Olga Goloubeva, Yukinori Take, Amy M. Fulton   +6 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Role of CD138⁺ Plasma Cells and Natural Killer Cells in Couple Infertility: A Review. [PDF]

Biomedicines
Messina A, Libretti A, Giovannini I, Leo L, Remorgida V, Masturzo B, Tinelli R.   +6 more
europepmc   +1 more source

In vivo and in vitro induction of natural killer cells by cloned human tumor necrosis factor

, 1988
R. Voth, S. Rossol, H. Gallati, I. Pracht, Hans P. Laubenstein, Georg Heß, W. E. G. M�ller, Heinz C. Schr�der, Christoph Jochum, K. H. Meyer zum B�schenfelde   +9 more
openalex   +2 more sources

Lamina Propria c-kit+ Immune Precursors Reside in Human Adult Intestine and Differentiate Into Natural Killer Cells [PDF]

, 2007
Hiroshi Chinen, Katsuyoshi Matsuoka, Toshiro Sato, Nobuhiko Kamada, Susumu Okamoto, Tadakazu Hisamatsu, Taku Kobayashi, Hirotoshi Hasegawa, Akira Sugita, Fukunori Kinjo, Jiro Fujita, Toshifumi Hibi∥   +11 more
openalex   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons? [PDF]

Pathogens
Preston H, Casey R, Ferris E, Kerr-Jones L, Jones L, Latif F, Clement M, Aicheler RJ, Wang ECY, Stanton RJ, Fielding CA.   +10 more
europepmc   +1 more source

Relation between uterine natural killer cells and unexplained recurrent miscarriage

, 2016
Ibrahim A. Abdelazim, Mohamed M. Farghali, Abdel-LatifG El-kholy, KhaledH Swidan, AhmedR Rashed, Ezzat Elsobky, MostafaF Goma   +6 more
openalex   +1 more source