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Testicular natural killer T‐cell lymphoma
International Journal of Urology, 2005Abstract Primary testicular lymphomas account for less than 5% of all testicular neoplasms. Testicular natural killer (NK)/T‐cell lymphomas are exceptional and have a very poor prognosis. We report the case of a 30‐year‐old French Caucasian man with testicular NK/T‐cell lymphoma of the following immunophenotype: CD2+, CD3ɛ+ and CD56+.
Charles, Ballereau +6 more
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Natural Killer T Cells and Asthma
New England Journal of Medicine, 2006Invariant natural killer T cells, originally characterized in mice and more recently defined in humans, are a unique, conserved T-cell sublineage possessing a rearrangement of the T-cell antigen receptor (Vα14Jα18 in mice and Vα24Jα18 in humans). Human natural killer T cells also have an invariant β chain (Vβ11). Vα24Vβ11 binds to glycolipids presented
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Beyond CAR-T cells: Natural killer cells immunotherapy
Medicina Clínica (English Edition), 2020Children and adolescents suffering from refractory leukaemia, relapse after stem cell transplantation, solid metastatic tumour or refractory to conventional treatments still condition a dismal prognosis. The critical role of the immune system in the immunosurveillance of cancer is becoming relevant with the development of new treatments such as the ...
María Dolores, Corral Sánchez +2 more
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Natural killer cells regulate diverse T cell responses
Trends in Immunology, 2013Natural killer (NK) cells are important mediators of the immune response against microbial pathogens and tumors. There is growing evidence from mouse and human studies that, NK cells exhibit immunoregulatory functions and can limit T cell immunity. NK cell regulatory activity has been demonstrated in a variety of disease models including chronic viral ...
Crome, Sarah Q +3 more
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Natural Killer T Cells in Mucosal Homeostasis
Annals of the New York Academy of Sciences, 2004Abstract: The mucosal‐associated lymphoid tissues (MALT), including the gut‐associated lymphoid tissues, are a tightly regulated environment. In fact, it might be stated that on the basis of studies from animal models of inflammatory bowel disease (IBD), the major means of peripheral regulation of immune responses in the intestine is not necessarily ...
Arthur, Kaser +6 more
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Imaging natural killer T cells in action
Immunology & Cell Biology, 2013Natural killer T (NKT) cells were first recognized more than two decades ago as a distinct lymphocyte lineage that regulates a broad range of immune responses. The activation of NKT cells paradoxically can lead to either suppression or stimulation of immune responses, but despite this uncertainty, many investigators are hopeful that immune therapies ...
Connie H Y, Wong, Paul, Kubes
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Natural killer T cells and ulcerative colitis
Cellular Immunology, 2019Ulcerative colitis (UC) is one of the two major forms of inflammatory bowel disease (IBD). Both innate immunity and adaptive immunity are aberrant in IBD. The pathogenesis of UC includes abnormal inflammation and immune responses of the digestive tract.
Li Jie, Lai, Jun, Shen, Zhi Hua, Ran
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Natural Killer T Cells and Autoimmune Disease
Current Molecular Medicine, 2009Natural killer T (NKT) cells are an unusual subset of innate immune cells that express a surface receptor generated by somatic DNA rearrangement, a hallmark of cells of the adaptive immune system. NKT cells express a highly restricted repertoire of T cell receptors that recognize glycolipid antigens bound with the antigen-presenting molecule CD1d.
Lan, Wu, Luc, Van Kaer
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Journal of Clinical Oncology, 2008
J. Vose, J. Armitage, D. Weisenburger
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J. Vose, J. Armitage, D. Weisenburger
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