Results 221 to 230 of about 10,859,059 (267)

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Dihydrotanshinone as a Natural Product-Based CYP17A1 Lyase Inhibitor for Hyperandrogenic Disorders. [PDF]

Biomolecules
Li K, Yakubu J, Jørgensen FS, Pandey AV.   +3 more
europepmc   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders. [PDF]

Angew Chem Int Ed Engl
Cheng XF, Lucas B, Lampe P, Ugel S, Chen S, Unger A, Bischoff M, Adariani SR, Naredla KR, Kumar K, Schmidt A, Strohmann C, Janning P, Gasper R, Lucas M, Gersch M, Sievers S, Bronte V, Ziegler S, Waldmann H.   +19 more
europepmc   +1 more source

Harnessing Photochemistry in Natural Product Synthesis: From Strategy to Applications. [PDF]

J Nat Prod
Taskinen EK, König B.
europepmc   +1 more source

Thiophene Derivatives as Versatile Precursors for (Hetero)Arene and Natural Product Synthesis. [PDF]

Angew Chem Int Ed Engl
Keimer A, Haut FL.
europepmc   +1 more source

Barettin, a Nonopioid, Nonhallucinogenic Marine Natural Product with Antihyperalgesic Properties Mediated by 5HT2A Inverse Agonism. [PDF]

J Nat Prod
Seekins CA, Okine M, Forrest EG, Chavez T, Stump A, Kaleeswaran V, Carr JE, Hulme C, Cardenas P, Vanderah TW, Streicher JM, Cartmell C.   +11 more
europepmc   +1 more source

The Role of Nucleotide Sequencing in Natural Product Drug Discovery. [PDF]

J Nat Prod
Waterworth SC.
europepmc   +1 more source

BisCEET: A Visual Browser for Biosynthetic Gene Clusters Aiding in the Identification of Natural Product Variants and Distinct Tailoring Enzymes. [PDF]

J Nat Prod
Sowa ST, Weddeling HG, Teufel R.
europepmc   +1 more source

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Artificial Intelligence For Natural Product Drug Discovery

Nature reviews. Drug discovery, 2023
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as machine learning have led to
Michael W. Mullowney, Katherine R. Duncan, S. Elsayed, Neha Garg, J. V. D. van der Hooft, N. Martin, David Meijer, Barbara R. Terlouw, Friederike Biermann, K. Blin, J. Durairaj, M. Gorostiola González, Eric J. N. Helfrich, Florian Huber, S. Leopold-Messer, Kohulan Rajan, Tristan de Rond, Jeffrey A. van Santen, Maria Sorokina, Marcy J. Balunas, M. Beniddir, D. V. van Bergeijk, L. Carroll, Chase M. Clark, Djork-Arné Clevert, C. Dejong, Chao Du, Scarlet Ferrinho, Francesca Grisoni, Albert Hofstetter, W. Jespers, Olga V. Kalinina, S. Kautsar, Hyunwoo Kim, Tiago F. Leão, J. Masschelein, E. Rees, R. Reher, Daniel Reker, P. Schwaller, Marwin H. S. Segler, M. Skinnider, A. Walker, E. Willighagen, B. Zdrazil, N. Ziemert, R. Goss, Pierre Guyomard, Andrea Volkamer, W. Gerwick, Hyun Uk Kim, Rolf Müller, G. V. van Wezel, G. V. van Westen, A. Hirsch, Roger G. Linington, Serina L. Robinson, M. Medema   +57 more
semanticscholar   +1 more source