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Strategic Use of Visible-Light Photoredox Catalysis in Natural Product Synthesis.

Chemical Reviews, 2021
Recent progress in the development of photocatalytic reactions promoted by visible light is leading to a renaissance in the use of photochemistry in the construction of structurally elaborate organic molecules.
S. P. Pitre, L. Overman
semanticscholar   +1 more source

Cytochrome P450 enzymes in fungal natural product biosynthesis.

Natural product reports (Print), 2021
Covering: 2015 to the end of 2020Fungal-derived polyketides, non-ribosomal peptides, terpenoids and their hybrids contribute significantly to the chemical space of total natural products.
Xingwang Zhang   +3 more
semanticscholar   +1 more source

Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota.

Natural product reports (Print), 2021
Covering: up to September 2020Mushroom-forming fungi of the division Basidiomycota have traditionally been recognised as prolific producers of structurally diverse and often bioactive secondary metabolites, using the methods of chemistry for research ...
Markus Gressler   +5 more
semanticscholar   +1 more source

Metabolic Engineering of Escherichia coli for Natural Product Biosynthesis.

Trends in Biotechnology, 2020
Natural products are widely employed in our daily lives as food additives, pharmaceuticals, nutraceuticals, and cosmetic ingredients, among others. However, their supply has often been limited because of low-yield extraction from natural resources such ...
Dongsoo Yang   +4 more
semanticscholar   +1 more source

Synthetic Biology in Natural Product Biosynthesis

Chemical Reviews
Synthetic biology has played an important role in the renaissance of natural products research during the post-genomics era. The development and integration of new tools have transformed the workflow of natural product discovery and engineering ...
Kaushik Seshadri   +6 more
semanticscholar   +1 more source

Progress in approved drugs from natural product resources.

Chinese Journal of Natural Medicines
Natural products (NPs) have consistently played a pivotal role in pharmaceutical research, exerting profound impacts on the treatment of human diseases.
Zhongwen Luo   +3 more
semanticscholar   +1 more source

Natural product pharmacology: the British Journal of Pharmacology perspective

British Journal of Pharmacology
Natural products (NPs) have long been used as a rich source of bioactive compounds for drug development. Recent technological advancements have revitalised natural products research as evidenced by increased publications in this field.
Xin Wang   +15 more
semanticscholar   +1 more source

Natural product-based nanoformulations for cancer therapy: Opportunities and challenges.

Seminars in Cancer Biology, 2019
Application of natural product-based nanoformulations for the treatment of different human diseases, such as cancer, is an emerging field. The conventional cancer therapeutic modalities, including surgery, chemotherapy, immunotherapy, radiotherapy has ...
Dharambir Kashyap   +9 more
semanticscholar   +1 more source

Natural product derived privileged scaffolds in drug discovery.

Current Opinion in Chemical Biology, 2019
The biological activity and structural diversity of natural products are unsurpassed by any available synthetic screening libraries. As such, these privileged scaffolds serve as important, biologically prevalidated platforms for the design of compound ...
Emma K. Davison, M. Brimble
semanticscholar   +1 more source

Synthetic biology and metabolic engineering of actinomycetes for natural product discovery.

Biotechnology Advances, 2019
Actinomycetes are one of the most valuable sources of natural products with industrial and medicinal importance. After more than half a century of exploitation, it has become increasingly challenging to find novel natural products with useful properties ...
E. Palazzotto, Y. Tong, S. Lee, T. Weber
semanticscholar   +1 more source

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