Results 101 to 110 of about 1,495,910 (392)

Radical Scavenging, Proteases Activities, and Phenolics Composition of Bark Extracts from 21 Medicinal Plants

Journal of Chemistry, 2015
Stem barks derived from twenty-one medicinal plants were extracted in methanol (100%) and acetone-water (70 : 30 v/v) and at room as well as at reflux temperature conditions.
Muhammad Asam Raza, Durre Shahwar, Tania Khan   +2 more
doaj   +1 more source

Characterization of Botanical and Geographical Origin of Corsican “Spring” Honeys by Melissopalynological and Volatile Analysis

Foods, 2014
Pollen spectrum, physicochemical parameters and volatile fraction of Corsican “spring” honeys were investigated with the aim of developing a multidisciplinary method for the qualification of honeys in which nectar resources are under-represented in the ...
Yin Yang, Marie-José Battesti, Jean Costa, Julien Paolini   +3 more
doaj   +1 more source

Geographic proximity and firm-university innovation linkages: evidence from Great Britain [PDF]

, 2008
We investigate evidence for spatially mediated knowledge transfer from university research. We examine whether firms locate their R&D labs near universities, and whether those that do are more likely to co-operate with, or source knowledge from ...
Abramovsky, L., Simpson, H.
core  

A direct urea fuel cell - power from fertiliser and waste [PDF]

, 2010
For the first time, a working direct urea and direct urine fuel cell has been developed to generate electricity directly from urea or ...
Bashyam, Boggs, Boggs, Bouchard, Ewing, Haile, Heffer, John T. S. Irvine, Kandlikar, Karim, Lu, Parikh, Park, Park, Prasad, Rong Lan, Ruiz-Morales, Schlapbach, Scott, Shanwen Tao, Simka, Steele, Tao, Tao, Tewari, Unlu, Varcoe, Verma, Wu   +28 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The potential chemo preventive effect of ursolic acid isolated from Paulownia tomentosa, against N-diethylnitrosamine: initiated and promoted hepatocarcinogenesis

Heliyon, 2019
The present study discusses the isolation of ursolic acid from the chloroform extract of Paulownia tomentosa (Thunb) Steud fruits and its cytotoxic effect has been assessed in-vitro was performed in different cells lines (A-549, MCF-7, HepG2) and in-vivo
Sanaa A. Ali, Nabaweya A. Ibrahim, Magdy M.D. Mohammed, Seham El-Hawary, Esraa A. Refaat   +4 more
doaj   +1 more source

Tuning artificial intelligence on the de novo design of natural-product-inspired retinoid X receptor modulators

Communications Chemistry, 2018
Instances of artificial intelligence equip medicinal chemistry with innovative tools for molecular design and lead discovery. Here we describe a deep recurrent neural network for de novo design of new chemical entities that are inspired by ...
D. Merk, F. Grisoni, Lukas Friedrich, G. Schneider   +3 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Computational structure-based identification of silymarin as a promising flavonoid inhibitor of the diphtheria toxin catalytic domain

Discover Chemistry
Diphtheria toxin, a major virulence factor of Corynebacterium diphtheriae, continues to pose significant therapeutic challenges in the face of antimicrobial resistance. Flavonoids, owing to their structural diversity and bioactivity, represent attractive
Chidi Edbert Duru, Favour Ogadinma Izuagba, Ijeoma Akunna Duru, Tochukwu Ifeanyi Nwakile, Chukwuebuka Daniel Nwadike   +4 more
doaj   +1 more source

New anthrarobin acyl derivatives as butyrylcholinesterase inhibitors: synthesis, in vitro and in silico studies

Heliyon, 2017
To treat Alzheimer's disease (AD), the available candidates are effective only against mild AD or have side effects. So, a study was planned to synthesis new candidates that may have good potential to treat AD.
Mehreen Lateef, Abid Azhar, Bina S. Siddiqui, Shamshad Zarina, Nizam uddin, Muhammad F. Anwar, Kauser Siddiqui, Kaniz F. Azhar, Lubna Iqbal, Rashad Mehmood, Shagufta Perveen   +10 more
doaj   +1 more source