Results 81 to 90 of about 1,189,605 (351)

Specioside (SS) & verminoside (VS) (Iridoid glycosides): isolation, characterization and comparable quantum chemical studies using density functional theory (DFT)

Heliyon, 2019
Two biologically important molecules specioside (SS) and verminoside (VS) have been isolated from the ethanolic extract of stem bark of Kigelia pinnata.
Monika Saini, Reetu Sangwan, Mohammad Faheem Khan, Ashok Kumar, Ruchi Verma, Sudha Jain   +5 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Production and characterization of activated carbons made from sunflower stems [PDF]

, 2012
Activated carbons (ACs) are artificial materials, prepared from natural or synthetic precursors that are worldwide extensively used. The ACs main characteristics are the noticeable adsorption capabilities provided by the highly developed porous structure
Carrott, Peter, Laginhas, Carlos, Ribeiro Carrott, Manuela, Valente Nabais, Joao   +3 more
core  

Free radical 5-exo-dig cyclization as the key step in the synthesis of bis-butyrolactone natural products: experimental and theoretical studies [PDF]

, 2011
Radical cyclization reactions were performed by 5-exo-dig mode to yield cis-fused bicyclic systems, leading to the synthesis of bis-butyrolactone class of natural products.
Allinger, Baldwin, Beckwith, Beckwith, Beckwith, Blot, Cossy, Curtiss, Devoju Harinada Chary, Florian Achrainer, Gangavaram V. M. Sharma, Hendrik Zipse, Lii, Lii, Nagula Chandramouli, Sateesh Patrudu, Sharma, Sharma, Sharma, Sharma, Sharma, Sharma, Srikrishna, Yu   +23 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Synthesis, crystal structures, Hirshfeld surface analysis and spectroscopic studies of two Schiff bases of anisaldehyde and their urease and acetylcholinesterase inhibitory and antioxidant properties

Heliyon, 2019
The growing demand of pharmaceutical industry for more effective drugs requires new molecules with promising medicinal activities. In the present work, a natural product anisaldehyde was treated with hydrazine and 3,5-dichloroaniline to synthesize their ...
Amber Jan Muhammad, Dildar Ahmed, Sammer Yousuf, Nida Tabassum, Muhammad Tariq Qamar   +4 more
doaj   +1 more source

Organocatalytic synthesis of axially chiral atropisomers [PDF]

, 2017
This review summarises the recent progress made in the organocatalytic synthesis of atropisomeric compounds. Methodologies based on dynamic kinetic resolution and direct access to BINOL-like biaryls are described.
Renzi, P.
core   +1 more source

Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance.

Journal of Medicinal Chemistry, 2019
Bacteria utilize multiple mechanisms that enable them to gain or acquire resistance to antibiotic therapies during the treatment of infections. In addition, bacteria form biofilms which are surface-attached communities of enriched populations containing ...
Y. Abouelhassan, Aaron T Garrison, Hongfen Yang, Alejandra Chávez-Riveros, Gena M. Burch, R. W. Huigens   +5 more
semanticscholar   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Bioinspired total syntheses of natural products: a personal adventure

Beilstein Journal of Organic Chemistry
Bioinspired total synthesis represents an important concept to guide the designing of powerful synthetic strategies. Our group has a long-time interest and experience in designing synthetic strategies through analyzing the biosynthetic pathway of natural
Zhengyi Qin, Yuting Yang, Nuran Yan, Xinyu Liang, Zhiyu Zhang, Yaxuan Duan, Huilin Li, Xuegong She   +7 more
doaj   +1 more source