Results 91 to 100 of about 1,205,213 (312)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Insights into the genetic and host adaptability of emerging porcine circovirus 3

Virulence, 2018
Porcine circovirus 3 (PCV3) was found to be associated with reproductive disease in pigs, and since its first identification in the United States, it subsequently spread worldwide, especially in China, where it might pose a potential threat to the ...
Gairu Li, Huijuan Wang, Shilei Wang, Gang Xing, Cheng Zhang, Wenyan Zhang, Jie Liu, Junyan Zhang, Shuo Su, Jiyong Zhou   +9 more
doaj   +1 more source

Increase in Complexity and Information through Molecular Evolution

Entropy, 2016
Biological evolution progresses by essentially three different mechanisms: (I) optimization of properties through natural selection in a population of competitors; (II) development of new capabilities through cooperation of competitors caused by ...
Peter Schuster
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Distinguishing Drift and Selection Empirically: “The Great Snail Debate” of the 1950s [PDF]

, 2007
Biologists and philosophers have been extremely pessimistic about the possibility of demonstrating random drift in nature, particularly when it comes to distinguishing random drift from natural selection.
Millstein, Roberta L.
core  

Experimental screening and selection criteria of natural coagulants towards wastewater treatment [PDF]

The search for eco-friendly materials has greatly evolved ahead of basic requirements encompassing sustainable practices. The selection of such sustainable material requires procedural systematic screening tests to facilitate decision-making.
Raj, Aman, Vara, Saritha, Dash, Swathi
core   +2 more sources

Correlated effects of selection for immunity in White Leghorn chicken lines on natural antibodies and specific antibody responses to KLH and M. butyricum [PDF]

, 2008
Background The effect of selection for three general immune response traits on primary antibody responses (Ab) to Mycobacterium butyricum or keyhole limpet hemocyanin (KLH) was studied in four experimental lines of White Leghorn chicken.
Gourichon, David, Pinard-van der Laan Marie-Helen, Bertrand Bed'hom, Francis Minvielle, H. K. Parmentier, Gourichon David, Nieuwland, M.G.B., F. Minvielle, Pinard-van Der Laan, Marie-Hélène, G. Minozzi, Sandrine Mignon-Grasteau, Nieuwland Mike GB, Henk K Parmentier, Parmentier, Henk K., Nieuwland, Mike G.B., Gourichon, D., Mignon-Grasteau, Sandrine,, Mignon-Grasteau, S., Mignon-Grasteau Sandrine, Parmentier Henk K, Minvielle Francis, Marie-Helen Pinard-van der Laan, Minozzi, Giulietta, Mike GB Nieuwland, Mignon-Grasteau, Sandrine, M. G. B. Nieuwland, Parmentier, H.K., Nieuwland, Mike GB, Bed'hom Bertrand, Grasteau, Sandrine, B. Bed'Hom, Minvielle, Francis, Pinard-van der Laan, M.H., Giulietta Minozzi, David Gourichon, Pinard-van der Laan, Marie-Helen, Minozzi, G., M. Pinard van der Laan, Parmentier, Henk, Bed'Hom, Bertrand, D. Gourichon, S. Mignon Grasteau, Minvielle, F., Pinard Van Der Laan, Marie-Hélène, Minozzi Giulietta, Bed'hom, B.   +45 more
core   +1 more source

Mitochondrial genomes of Macropsini (Hemiptera: Cicadellidae: Eurymelinae): Structural features, codon usage patterns, and phylogenetic implications

Ecology and Evolution
Macropsini is a tribe of Eurymelinae in the family Cicadellidae that is widely distributed worldwide. Still, its taxonomic status has been unstable, and the classification of certain clades at the genus level has been controversial. The aim of this study
Meishu Guo, JiaJia Wang, Hu Li, Kai Yu, Yanqiong Yang, Min Li, Guy Smagghe, RenHuai Dai   +7 more
doaj   +1 more source

Evolutionary insights into duffy gene in mammalian taxa with comparative genetic analysis [PDF]

Journal of Vector Borne Diseases, 2009
Background & objectives: Evolutionary analyses of genes conserved across taxa are keys tounderstand the complexity of gene and genome variation. Since malaria is a highly infectioushuman disease and its susceptibility in human is genetically controlled ...
Gauri Awasthi, Aditya P. Dash
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source