Results 91 to 100 of about 4,039,102 (286)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Ecology and EvolutionMacropsini is a tribe of Eurymelinae in the family Cicadellidae that is widely distributed worldwide. Still, its taxonomic status has been unstable, and the classification of certain clades at the genus level has been controversial. The aim of this study
Meishu Guo +7 more
doaj +1 more source
Evolutionary insights into duffy gene in mammalian taxa with comparative genetic analysis [PDF]
Journal of Vector Borne Diseases, 2009 Background & objectives: Evolutionary analyses of genes conserved across taxa are keys tounderstand the complexity of gene and genome variation. Since malaria is a highly infectioushuman disease and its susceptibility in human is genetically controlled ...
Gauri Awasthi, Aditya P. Dash
doaj
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Natural Selection and the Evolution of Life Expectancy [PDF]
This research advances an evolutionary growth theory that captures the pattern of life expectancy in the process of development, shedding new light on the sources of the remarkable rise in life expectancy since the Agricultural Revolution.
Oded Galor, Omer Moav
core +6 more sources
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
The intricate relationship between plants and their environment has fascinated scientists and naturalists for centuries. As foundational components of ecosystems, plants play a crucial role in maintaining the balance of nature, influencing climate, supporting diverse life forms, and contributing to the Earth's biogeochemical cycles. Equally captivating
Soni, Kamlesh, Koshe, Paras
+5 more sources
Why do we age? The main signs of aging
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta PraktikiAging is a gradual and irreversible pathophysiological process. This is manifested in the decline of tissue and cell functions and a significant variety of pathologies associated with aging, including neurodegenerative diseases, cardiovascular diseases ...
Ugіs Kletnieks +3 more
doaj +1 more source
Biomolecules, 2014 The properties of biomolecules depend both on physics and on the evolutionary process that formed them. These two points of view produce a powerful synergism.
Ugo Bastolla
doaj +1 more source