Results 81 to 90 of about 1,099,029 (313)

Why do we age? The main signs of aging

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Aging is a gradual and irreversible pathophysiological process. This is manifested in the decline of tissue and cell functions and a significant variety of pathologies associated with aging, including neurodegenerative diseases, cardiovascular diseases ...
Ugіs Kletnieks, Audrius Butkevichius, V. V. Hladyshev, S. S. Sоkolovskyi   +3 more
doaj   +1 more source

Detecting Selection on Protein Stability through Statistical Mechanical Models of Folding and Evolution

Biomolecules, 2014
The properties of biomolecules depend both on physics and on the evolutionary process that formed them. These two points of view produce a powerful synergism.
Ugo Bastolla
doaj   +1 more source

Transfer of individuals as a means of investigating natural selection in operation [PDF]

, 2009
Olli Halkka, Liisa Halkka, Mikko Raatikainen   +2 more
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

SELECTION OF NATURAL ANALOGUES FOR GEOLOGICAL MODELING OF TERRIGENIC HYDROCARBON RESERVOIRS

, 2021
M.V. Rykus, А. В. Сначев
openalex   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Population genomic evidence of structured and connected Plasmodium vivax populations under host selection in Latin America

Ecology and Evolution
Pathogen genomic epidemiology has the potential to provide a deep understanding of population dynamics, facilitating strategic planning of interventions, monitoring their impact, and enabling timely responses, and thereby supporting control and ...
Johanna Helena Kattenberg, Pieter Monsieurs, Julie De Meyer, Katlijn De Meulenaere, Erin Sauve, Thaís C. deOliveira, Marcelo U. Ferreira, Dionicia Gamboa, Anna Rosanas‐Urgell   +8 more
doaj   +1 more source

Aristotle and Natural Selection [PDF]

, 1908
F. A. Dixey
openalex   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Haplotype Structure and Natural Selection in an Olfactory Receptor (OR) Gene on Chromosome 6p Associated with Asthma Susceptibility [PDF]

, 2006
Emma E. Thompson, Carly Mychl Murray, Melissa C. Burkart, Dan L. Nicolae, Yoav Gilad, Carole Ober   +5 more
openalex   +1 more source