Results 71 to 80 of about 14,815,342 (343)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
What is adaptation by natural selection? Perspectives of an experimental microbiologist
PLoS Genetics, 2017 Ever since Darwin, the role of natural selection in shaping the morphological, physiological, and behavioral adaptations of animals and plants across generations has been central to understanding life and its diversity.
R. Lenski
semanticscholar +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Informational selection & natural selection
Physics Procedia, 2010 The Natural Selection Principle plays an important role in Darwinian evolution theory for the world of biology; its success and reasoning power have persuaded many people that there should be a similar principle for social, economic phenomena. After all, the current economy is a much faster evolutionary process. Unlike in the history of evolution where
openaire +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Empirical approaches to detecting the action of natural selection in Drosophila [PDF]
, 2004 This dissertation examines two aspects of how natural selection shapes the amount and pattern of genetic variation within and between species: (1) the role of positively selected alleles in shaping the variation within and between subpopulations of a ...
Baines, John
core +1 more source
Natural Induction: Spontaneous Adaptive Organisation without Natural Selection
EntropyEvolution by natural selection is believed to be the only possible source of spontaneous adaptive organisation in the natural world. This places strict limits on the kinds of systems that can exhibit adaptation spontaneously, i.e., without design ...
Christopher L. Buckley +5 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
MAHONIA AQUIFOLIUM AS A PROMISING RAW MATERIAL FOR THE FOOD INDUSTRY
Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2017 The development of the food industry leads to the expansion of the range of processed raw materials. Mahonia aquifolium today can be attributed to the non-traditional agricultural plants.
VLADIMIR N. SOROKOPUDOV +2 more
doaj
Other title: Title from HTML header (viewed Nov. 9, 2011): Judicial Selection Commission
, 2011 Updated irregularly; Began in 2002?; Title from main search screen (publisher's Web site, viewed Nov. 9, 2011).; At head of title: State of Connecticut.; Harvested from the web on 11/10/11Official website of the Connecticut Judicial Selection Commission.
core +1 more source