Results 121 to 130 of about 3,774,779 (338)
On the Origin of Species by Means of Natural Selection
, 1953 R. L. Livezey, Charles Darwin
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Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
GENETICS OF NATURAL POPULATIONS. XVI. ALTITUDINAL AND SEASONAL CHANGES PRODUCED BY NATURAL SELECTION IN CERTAIN POPULATIONS OF DROSOPHILA PSEUDOOBSCURA AND DROSOPHILA PERSIMILIS [PDF]
, 1948 Theodosius Dobzhansky
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Panmixia and Natural Selection [PDF]
Nature, 1894 MR. AVELDON'S letter on this subject, in NATURE of May 3, calls, I think, for a few farther observations. He first criticises the statement that “the survival-mean must, on cessation of selection, fall to the birth-mean,” by showing that there are probably cases in nature in which the survival and birth-means may coincide, owing to the removal by ...
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
The power of natural selection [PDF]
, 2002 In a recent paper, Steven Horst argued that if traditional physicalist accounts of consciousness cannot explain why there are conscious phenomena in the world then teleological accounts of consciousness that appeal to the notion of natural selection ...
Macpherson, F.
core
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
AN EXPERIMENTAL STUDY OF INTERACTION BETWEEN GENETIC DRIFT AND NATURAL SELECTION [PDF]
, 1957 Theodosius Dobzhansky, Olga Pavlovsky
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Molecular Oncology, EarlyView.Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
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