Results 81 to 90 of about 3,493,599 (282)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Management approach matters: meeting seagrass recovery and carbon mitigation goals

npj Ocean Sustainability
Seagrass habitats support biodiversity, improve water quality, protect coastlines, and sequester carbon, among other essential ecosystem functions, yet they are declining worldwide due to human activity.
Melissa Ward, Connor Dibble, Maddie Millington-Drake, John Lynch, Karen McGlathery, Richard J. Lilley, Aaron L. Strong, Lisa M. Wedding   +7 more
doaj   +1 more source

Wave dynamics and potential longshore sediment transport at Shippagan, Gulf of St Lawrence: insight into seasonal variability and extreme weather events

Frontiers in Marine Science
This study examines the wave climate and its influence on potential Longshore Sediment Transport (LST) along the Shippagan coast of the Gulf of St. Lawrence, eastern Canada.
Jubin Thomas, Jubin Thomas, Jesbin George, Danika Van Proosdij, Danika Van Proosdij, Enda Murphy   +5 more
doaj   +1 more source

Trust but verify: The case for astrophysical black holes

, 2005
This article is based on a pair of lectures given at the 2005 SLAC Summer Institute. Our goal is to motivate why most physicists and astrophysicists accept the hypothesis that the most massive, compact objects seen in many astrophysical systems are ...
Hughes, Scott A.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Peatland restoration is anticipated to provide climate change mitigation over all time-scales: a UK case-study

Environmental Research Communications
Peatlands provide one of the largest terrestrial carbon stocks in the UK, but a large proportion of peatlands have been drained for peat extraction, agriculture and other uses, turning them into a major source of greenhouse gas (GHG) emissions ...
Xiao Zhang, Minna Ots, Eleanor Johnston, Kathryn Brown, Nigel Doar, John Lynch   +5 more
doaj   +1 more source

Nature-based solutions: criteria [PDF]

Nature, 2017
Christian, Albert, Joachim H, Spangenberg, Barbara, Schröter   +2 more
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Exploring the Energy Potential of Residual Biomass: A Bibliometric Analysis

Energies
The increasing challenge of waste disposal and the growing demand for reliable renewable energy sources are particularly critical in developing countries.
Jairo Ceballos-Sandoval, Alexander D. Pulido-Rojano, Hegel Rincón-Laurens, Bertha Villalobos-Toro, Oscar Ospino-Toro, Ray Rincón-Laurens, Javier Restrepo-Vieco   +6 more
doaj   +1 more source