Results 91 to 100 of about 5,918,329 (258)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Comparative Analysis of Complete Chloroplast Genomes of Anemoclema, Anemone, Pulsatilla, and Hepatica Revealing Structural Variations Among Genera in Tribe Anemoneae (Ranunculaceae)

Frontiers in Plant Science, 2018
Structural rearrangements of Anemone species' chloroplast genome has been reported based on genetic mapping of restriction sites but has never been confirmed by genomic studies.
Huijie Liu, Jian He, Chuanhua Ding, Rudan Lyu, Linying Pei, Jin Cheng, Lei Xie   +6 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Conservation in Kansas

, 2008
Report covers Fiscal Year 2007 and 2008, with planned activities listed for Fiscal Year 2009.<br>Continues title: Soil conservation in Kansas which previously was continued by: Conservation in ...
Kansas. State Conservation Commission
core  

Comparison Between the Fecal Bacterial Microbiota of Healthy and Diarrheic Captive Musk Deer

Frontiers in Microbiology, 2018
Diarrhea constitutes one of the most common diseases affecting the survival of captive musk deer and is usually caused by an imbalance in intestinal microbiota.
Yimeng Li, Xiaolong Hu, Shuang Yang, Juntong Zhou, Lei Qi, Xiaoning Sun, Mengyuan Fan, Shanghua Xu, Muha Cha, Meishan Zhang, Shaobi Lin, Shuqiang Liu, Shuqiang Liu, Defu Hu   +13 more
doaj   +1 more source

Nature conservation versus climate protection: a basic conflict of goals regarding the acceptance of climate protection measures? [PDF]

Front Psychol, 2023
Blöbaum A, Engel L, Beer K, Böcher M, Matthies E.   +4 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Conservation status of New Zealand freshwater invertebrates, 2013 [PDF]

, 2014
The conservation status of 644 freshwater invertebrate taxa, across five Phyla, 28 Orders and 75 Families, was assessed using the New Zealand Threat Classification System (NZTCS) criteria.
Collier, Kevin J., Grainger, N., Hitchmough, Rodney, Smith, Brian J., Harding, J.S., Harding, Jon S., Sutherland, Darin Lee   +6 more
core  

Primate surveys and conservation assessments [PDF]

, 2008
From first paragraph: The conservation of the world’s primates demands basic, but elusive and hard-to-get, information. Enormous efforts are underway to accumulate this information, and the fortuitous selection of six papers in this issue of Oryx ...
Williamson, Elizabeth A, Rylands, Anthony B, Mittermeier, Russell A, Hoffmann, Michael   +3 more
core   +1 more source