Results 81 to 90 of about 5,918,329 (258)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Ethics in conservation

, 2019
During recent years the relevance of environmental ethics to nature conservation has been increasingly questioned. This doubt mainly takes two forms: (1) Conservation biology is regarded as solely a scientific endeavor, and therefore ethics is redundant;
Sveriges lantbruksuniversitet., Baard, Patrik,   +1 more
core   +1 more source

Genetic diversity and structure of Mongolian gazelle (Procapra gutturosa) in fragmented habitats

BMC Genomics
Background Mongolian gazelle (Procapra gutturosa) populations have experienced significant range contraction and fragmentation over the past century due to habitat loss and barriers.
Sijia Gao, Ding Zhou, Zhichao Zhou, Yiting Liu, Xinghu Qin, Dong Zhang   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Making the linkages : conservation as a core asset for livelihood security in Eastern Africa; final report (March 2010 - February 2011)

, 2011
The purpose of this project was to gather, disseminate and influence knowledge on conservation and biodiversity at the right levels of decision making so that conservation and biodiversity are better integrated as key ...
International Union for Conservation of Nature
core   +1 more source

The new genus Bambusiporia and a new species of Etheirodon in Steccherinaceae (Polyporales, Basidiomycota) from China [PDF]

MycoKeys
Steccherinaceae is a speciose family of wood-inhabiting fungi containing various hymenophore configurations. Phylogenetic and morphological analyses of Steccherinaceae were carried out.
Chao-Ge Wang, Xin Zhang, Zhan-Bo Liu, Jian Chen, Yi-Fei Sun, Yu-Cheng Dai, Ying-Da Wu   +6 more
doaj   +3 more sources

Bioinspired robots can foster nature conservation. [PDF]

Front Robot AI, 2023
Chellapurath M, Khandelwal PC, Schulz AK.   +2 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Nature Conservation and Nature-Based Tourism: A Paradox?

, 2019
Throughout the world, areas have been reserved for their exceptional environmental values, such as high biodiversity. Financial, political and community support for these protected areas is often dependent on visitation by nature-based tourists.
Isabelle D. Wolf, Green, Ronda J, Ronda J. Green, Croft, David B, Wolf, Isabelle D, David B. Croft   +5 more
core   +1 more source