Results 61 to 70 of about 5,918,329 (258)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Rewilding European Landscapes [PDF]
, 2015 Nature Conservation; Environmental Management; Biodiversity; Landscape Ecology; Applied ...
core +2 more sources
Koedoe: African Protected Area Conservation and Science, 1993 Morphometric data of 92 adult mountain reedbuck are presented. Males were significantly heavier than females, and the tails of the males were significantly longer than those of the females.
M.D. Andersen, J.H. Koen
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Nature calls: a series of nature-based outdoor activities [PDF]
, 2016 Did you know that the outdoors, teeming with plants, animals, birds and insects can transform into an immersive and captivating classroom? Nature Calls is a series of nature-based activities designed to encourage students to explore their surroundings ...
Nature Conservation Foundation,
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Health and wellbeing benefits of conservation in New Zealand [PDF]
, 2013 : Despite a long-held popular belief that nature is ‘healthy’ for people, exactly how or even whether this is true has only recently been subject to scientific scrutiny. This report reviews key literature relevant to the relationship between conservation
Paul Blaschke
core
, 2011 Report covers Fiscal Year 2010 and 2011, with planned activities listed for Fiscal Year 2012.<br>Continues title: Soil conservation in Kansas which previously was continued by: Conservation in ...
Kansas. State Conservation Commission
core +1 more source