Results 51 to 60 of about 5,918,329 (258)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Family structure influences the gut microbiota of the Sino-Mongolian beaver (Castor fiber birulai) rather than age and genderNCBI Sequence Read Archive (SRA)

Global Ecology and Conservation
Gut microbiota is crucial for the health and survival of wildlife. In this study, metagenomic analysis was performed on fecal samples of endangered Sino-Mongolian beavers (Castor fiber birulai) from three groups rescued in the wild, to explore the ...
Wenwen Chu, Zhichao Zhou, Xiaoyun Li, Chi Ma, Yuting Gao, Wenpu Huang, Fangyi Liu, Dong Zhang, Kai Li   +8 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Comparative Analysis of Gut Microbiota Changes in Père David's Deer Populations in Beijing Milu Park and Shishou, Hubei Province in China

Frontiers in Microbiology, 2018
This study used 16S rRNA high-throughput sequencing technology to examine the differences in gut microbiota between the Père David's deer populations in the Beijing and Shishou areas of China in order to understand the effects of ex situ conservation on ...
Meishan Zhang, Minghui Shi, Mengyuan Fan, Shanghua Xu, Yimeng Li, Tianxiang Zhang, Muha Cha, Yang Liu, Xiaobing Guo, Qi Chen, Yiping Li, Shumiao Zhang, Defu Hu, Shuqiang Liu   +13 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Evidence for dilution effect by Gobio gobio, a dead-end host in the Unio crassus–Cyprinidae coevolutionary system

Scientific Reports
Freshwater mussels (Unionidae) depend on specific fish hosts to complete their life cycle. Glochidia, their parasitic larvae, must attach to the gills or fins of suitable fish species to metamorphose.
Jacek Dołęga, Tadeusz A. Zając, Adam Ćmiel, Anna Lipińska, Krzysztof Tatoj, Katarzyna Zając   +5 more
doaj   +1 more source

Transcriptome analysis revealed potential mechanisms of differences in physiological stress responses between caged male and female magpies

BMC Genomics, 2019
Background Under caged conditions, birds are affected more severely by environmental stressors such as dietary structure, activity space, human disturbances, and pathogens, which may be reflected in the gene expression in peripheral blood or other ...
Yu Wang, Jinxin Guo, Lin Wang, Hengjiu Tian, Jinling Sui   +4 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Nature connectedness, nonattachment and engagement with nature’s beauty predict pro-nature conservation behaviour

, 2022
Although research has examined factors that account for proenvironmental behaviors relating to climate warming through carbon and resource use, very few studies have investigated factors that account for behavior that directly supports conservation of ...
Hamlin, I., Barrows, P., Richardson, M., Van Gordon, W.   +3 more
core   +1 more source